2. Gene
  3. SLC7A2 - solute carrier family 7 member 2 Gene

SLC7A2 - solute carrier family 7 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 7 成员 2

种属: Homo sapiens

同用名: CAT2; ATRC2; HCAT2

基因 ID: 6542 | 基因类型: protein coding

关于 SLC7A2

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,494,069-17,570,566 (from NCBI)

This gene has 6 transcripts (splice variants), 244 orthologues and 12 paralogues. Broad expression in liver (RPKM 59.2), thyroid (RPKM 35.6) and 15 other tissues.

功能概要

该基因编码的蛋白质是一种阳离子氨基酸转运蛋白，是 APC (氨基酸-多胺-有机阳离子) 转运蛋白家族的成员。编码的膜蛋白负责精氨酸、赖氨酸和鸟氨酸的细胞摄取。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is a cationic Amino acid Transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SLC7A2 基因产物(5)

mRNA Protein Name
NM_001008539.4 NP_001008539.3 cationic amino acid transporter 2 isoform 2
NM_001164771.2 NP_001158243.1 cationic amino acid transporter 2 isoform 3
NM_001370337.1 NP_001357266.1 cationic amino acid transporter 2 isoform 4
NM_001370338.1 NP_001357267.1 cationic amino acid transporter 2 isoform 2
NM_003046.6 NP_003037.4 cationic amino acid transporter 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-amino acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
23864433 GOA
enables L-arginine transmembrane transporter activity IDA
IDA: 通过直接分析推断
9174363 GOA
enables amino acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
28684763 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-alpha-amino acid transmembrane transport IDA
IDA: 通过直接分析推断
23864433 GOA
involved in L-amino acid transport IDA
IDA: 通过直接分析推断
28684763 GOA
involved in L-arginine import across plasma membrane IDA
IDA: 通过直接分析推断
23864433 GOA
involved in L-arginine transmembrane transport IDA
IDA: 通过直接分析推断
9174363 GOA
involved in amino acid import across plasma membrane IDA
IDA: 通过直接分析推断
23864433 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC7A2 蛋白结构

AA_permease_2

AA_permease_2: Amino acid permease (34 - 436)

AA_permease_C

AA_permease_C: C-terminus of AA_permease (556 - 606)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
蛋白主名 其他名称

cationic amino acid transporter 2

low affinity cationic amino acid transporter 2

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS21940 Slc7a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13328 SLC7A2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC7A2 RGD RGD:68387
Canis familiaris SLC7A2 VGNC VGNC:46474
Mus musculus SLC7A2 MGD MGI:99828
Bos taurus SLC7A2 VGNC VGNC:34928
Macaca mulatta SLC7A2 VGNC VGNC:77629
Felis catus SLC7A2 VGNC VGNC:65425
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