2. Gene
  3. SLCO1A2 - solute carrier organic anion transporter family member 1A2 Gene

SLCO1A2 - solute carrier organic anion transporter family member 1A2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体有机阴离子转运蛋白家族成员 1A2

种属: Homo sapiens

同用名: OATP; OATP-A; OATP1A2; SLC21A3

基因 ID: 6579 | 基因类型: protein coding

关于 SLCO1A2

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,264,600-21,419,634 (from NCBI)

This gene has 17 transcripts (splice variants), 159 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues.

功能概要

该基因编码一种钠非依赖性转运蛋白，介导肝脏中细胞对有机离子的摄取。其底物包括胆汁酸、溴磺酞和一些甾体化合物。该蛋白质是 SLC21A 溶质载体家族的成员。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2008 年 12 月]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

SLCO1A2 基因产物(37)

mRNA Protein Name
NM_001386878.1 NP_001373807.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386879.1 NP_001373808.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386880.1 NP_001373809.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386881.1 NP_001373810.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386882.2 NP_001373811.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386886.1 NP_001373815.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386887.1 NP_001373816.1 solute carrier organic anion transporter family member 1A2 isoform 4
NM_001386890.1 NP_001373819.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386908.1 NP_001373837.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386919.1 NP_001373848.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386920.1 NP_001373849.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386921.1 NP_001373850.1 solute carrier organic anion transporter family member 1A2 isoform 10 precursor
NM_001386922.1 NP_001373851.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386926.1 NP_001373855.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386927.1 NP_001373856.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386929.1 NP_001373858.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386931.1 NP_001373860.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386937.1 NP_001373866.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386938.1 NP_001373867.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386939.1 NP_001373868.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386940.1 NP_001373869.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386946.1 NP_001373875.1 solute carrier organic anion transporter family member 1A2 isoform 7 precursor
NM_001386947.1 NP_001373876.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386948.1 NP_001373877.1 solute carrier organic anion transporter family member 1A2 isoform 3 precursor
NM_001386949.1 NP_001373878.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386951.1 NP_001373880.1 solute carrier organic anion transporter family member 1A2 isoform 6 precursor
NM_001386952.1 NP_001373881.1 solute carrier organic anion transporter family member 1A2 isoform 3 precursor
NM_001386953.1 NP_001373882.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386954.1 NP_001373883.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386958.1 NP_001373887.1 solute carrier organic anion transporter family member 1A2 isoform 5 precursor
NM_001386959.1 NP_001373888.1 solute carrier organic anion transporter family member 1A2 isoform 9 precursor
NM_001386960.1 NP_001373889.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386961.1 NP_001373890.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386962.1 NP_001373891.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386963.1 NP_001373892.1 solute carrier organic anion transporter family member 1A2 isoform 12
NM_021094.4 NP_066580.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_134431.5 NP_602307.1 solute carrier organic anion transporter family member 1A2 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
10873595 GOA
enables transmembrane transporter activity IDA
IDA: 通过直接分析推断
25132355 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
25132355 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLCO1A2 蛋白结构

OATP

OATP: Organic Anion Transporter Polypeptide (OATP) family (20 - 598)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (445 - 486)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
蛋白主名 其他名称

solute carrier organic anion transporter family member 1A2

OATP-1

关联疾病

疾病名称 别名
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Carbapenem Allergy
Intrahepatic Cholestasis

Cholestasis, Intrahepatic

Neonatal Intrahepatic Cholestasis

Cholestasis Intrahepatic

Cholestasis Of Pregnancy
Cholelithiasis
Allan-Herndon-Dudley Syndrome

AHDS

Allan-Herndon Syndrome

Monocarboxylate Transporter 8 Deficiency

MCT8 DEFICIENCY

Mental Retardation, X-Linked, With Hypotonia

Triiodothyronine Resistance

T3 Resistance

Mental Retardation And Muscular Atrophy

Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency

Intellectual Disability And Muscular Atrophy

Monocarboxylate Transporter-8 Deficiency

T3 Resisitence

Triiodothyronine Resistence

X-Linked Intellectual Disability With Hypotonia

Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency

Monocarboxylate Transporter 8 Deficiency

X-Linked Intellectual Disability-Hypotonia Syndrome
Dubin-Johnson Syndrome

DJS

Chronic Idiopathic Jaundice

Jaundice, Chronic Idiopathic

Hyperbilirubinemia, Dubin-Johnson Type

Hyperbilirubinemia Ii

Hyperbilirubinemia Type 2

Conjugated Hyperbilirubinemia

Dubin-Sprinz Disease

Sprinz-Nelson Syndrome

Hblrdj

Dubin Johnson Syndrome

Hyperbilirubinemia 2

Black Liver-Jaundice Syndrome

Chronic Idiopathic Jaundice With Pigmented Liver

Dubin-Sprinz Syndrome

Hyperbilirubinaemia Type 2

Djs - [Dubin-Johnson Syndrome]
Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis

BRIC1

Summerskill Syndrome

Bric

Summerskill-Walshe-Tygstrup Syndrome

Cholestasis, Benign Recurrent Intrahepatic

Benign Recurrent Intrahepatic Cholestasis 1

Benign Recurrent Intrahepatic Cholestasis Type 1

Bric Type 1

Low Gamma-Gt Familial Intrahepatic Cholestasis

Recurrent Familial Intrahepatic Cholestasis

Cholestasis, Benign Recurrent Intrahepatic 1

Mild Atp8b1 Deficiency

Recurrent Familial Intrahepatic Cholestasis 1

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3

Bric - [Benign Recurrent Intrahepatic Cholestasis]
Extrahepatic Cholestasis

Cholestasis, Extrahepatic

Extrahepatic Biliary Stasis

Extrahepatic Obstructive Biliary Disease

Cholestasis Extrahepatic
Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy

Gravidic Intrahepatic Cholestasis

Pregnancy-Related Cholestasis

Icp

Pregnancy Related Cholestasis

Cholestasis, Intrahepatic Of Pregnancy

Familial Intrahepatic Cholestasis Of Pregnancy

Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

Ricp

Obstetric Cholestasis
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Gilbert Syndrome

Gilbert Disease

Gilbert'S Disease

Gilbert'S Syndrome

Cholemia, Familial

Familial Nonhemolytic Jaundice

Meulengracht Syndrome

Gilbert Syndrome, Susceptibility To

Hyperbilirubinemia, Gilbert Type

Hblrg

Hyperbilirubinemia, Arias Type

Hyperbilirubinemia I

Constitutional Hyperbilirubinemia

Gilbert-Meulengracht Syndrome

Hereditary Nonhemolytic Jaundice

Hyperbilirubinemia Arias Type

Hyperbilirubinemia Type 1

Constitutional Liver Dysfunction

Gilbert-Lereboullet Syndrome

Hyperbilirubinemia 1

Unconjugated Benign Bilirubinemia

GILBS

Gilberts Syndrome

Familial Nonhaemolytic Jaundice

Constitutional Hyperbilirubinaemia

Hereditary Nonhaemolytic Bilirubinaemia

Familial Nonhaemolytic Bilirubinaemia

Idiopathic Hyperbilirubinaemia

Icterus Intermittens Juvenilis

Chronic Intermittent Juvenile Jaundice

Low-Grade Chronic Hyperbilirubinaemia Syndrome

Benign Unconjugated Bilirubinaemia Syndrome

Hereditary Nonhaemolytic Jaundice

Idiopathic Unconjugated Hyperbilirubinaemia

Gilbert--Lereboullet Syndrome

Constitutional Hepatic Dysfunction

Meulengracht Icterus

Cholaemia Familiaris Simplex

Familial Cholaemia

Congenital Familial Cholaemia

Physiologic Cholaemia

Hyperbilirubinaemia Type 1

Gilbert Cholaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13351 SLCO1A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SLCO1A2 VGNC VGNC:65442
Macaca mulatta SLCO1A2 VGNC VGNC:77601
Canis familiaris SLCO1A2 VGNC VGNC:46493
Bos taurus SLCO1A2 VGNC VGNC:34949
Rattus norvegicus SLCO1A2 RGD RGD:621389
Others SLCO1A2 NCBI
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