SLC22A2 - solute carrier family 22 member 2 Gene

中文名称：溶质载体家族 22 成员 2

种属: Homo sapiens

同用名: OCT2

基因 ID: 6582 | 基因类型: protein coding

关于 SLC22A2

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,216,755-160,258,821 (from NCBI)

This gene has 6 transcripts (splice variants), 327 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 70.1).

功能概要

肝脏、肾脏、肠道和其他器官中的多特异性有机阳离子转运蛋白对于消除许多内源性小有机阳离子以及多种药物和环境毒素至关重要。该基因是位于 6 号染色体簇中的三个相似阳离子转运蛋白基因之一。编码的蛋白质包含十二个假定的跨膜结构域，是一种血浆整合膜蛋白。它主要存在于肾脏中，在那里它可能介导阳离子重吸收的第一步。[RefSeq 提供，2008 年 7 月]

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

SLC22A2 基因产物(1)

mRNA	Protein	Name
NM_003058.4	NP_003049.2	solute carrier family 22 member 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-amino acid transmembrane transporter activity	IMP IMP: 通过突变表型推断	23864433	GOA
enables L-arginine transmembrane transporter activity	IMP IMP: 通过突变表型推断	23864433	GOA
enables acetylcholine transmembrane transporter activity	IDA IDA: 通过直接分析推断	15817714	GOA
enables amine transmembrane transporter activity	IDA IDA: 通过直接分析推断	9687576	GOA
enables choline transmembrane transporter activity	IDA IDA: 通过直接分析推断	9687576	GOA
enables efflux transmembrane transporter activity	IDA IDA: 通过直接分析推断	9687576	GOA
enables monoamine transmembrane transporter activity	IDA IDA: 通过直接分析推断	9687576	GOA
enables neurotransmitter transmembrane transporter activity	IDA IDA: 通过直接分析推断	9687576	GOA
enables organic anion transmembrane transporter activity	IDA IDA: 通过直接分析推断	11907186	GOA
enables organic cation transmembrane transporter activity	EXP EXP: 通过实验结果推断	19141712	GOA
enables organic cation transmembrane transporter activity	IDA IDA: 通过直接分析推断	9260930	GOA
enables organic cation transmembrane transporter activity	IMP IMP: 通过突变表型推断	23864433	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: 通过直接分析推断	11907186	GOA
enables putrescine transmembrane transporter activity	IDA IDA: 通过直接分析推断	21128598	GOA
enables pyrimidine nucleoside transmembrane transporter activity	IMP IMP: 通过突变表型推断	20477935	GOA
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: 通过直接分析推断	9260930	GOA
enables thiamine transmembrane transporter activity	IDA IDA: 通过直接分析推断	24961373	GOA
enables toxin transmembrane transporter activity	IDA IDA: 通过直接分析推断	9687576	GOA
enables toxin transmembrane transporter activity	IMP IMP: 通过突变表型推断	20477935	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: 通过直接分析推断	12395288	GOA
enables xenobiotic transmembrane transporter activity	IMP IMP: 通过突变表型推断	20477935	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in L-alpha-amino acid transmembrane transport	IMP IMP: 通过突变表型推断	23864433	GOA
involved in L-arginine import across plasma membrane	IMP IMP: 通过突变表型推断	23864433	GOA
involved in acetylcholine transport	IDA IDA: 通过直接分析推断	15817714	GOA
involved in amine transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in amino acid import across plasma membrane	IMP IMP: 通过突变表型推断	23864433	GOA
involved in cellular detoxification	IDA IDA: 通过直接分析推断	9687576	GOA
involved in cellular detoxification	IMP IMP: 通过突变表型推断	20477935	GOA
involved in choline transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in dopamine transport	IDA IDA: 通过直接分析推断	16581093	GOA
involved in dopamine uptake	IDA IDA: 通过直接分析推断	9687576	GOA
involved in epinephrine transport	IDA IDA: 通过直接分析推断	16581093	GOA
involved in export across plasma membrane	IDA IDA: 通过直接分析推断	9687576	GOA
involved in histamine transport	IDA IDA: 通过直接分析推断	16581093	GOA
involved in histamine uptake	IDA IDA: 通过直接分析推断	9687576	GOA
involved in neurotransmitter transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in norepinephrine transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in norepinephrine uptake	IDA IDA: 通过直接分析推断	9687576	GOA
acts upstream of or within organic cation transport	IDA IDA: 通过直接分析推断	16024787	GOA
involved in organic cation transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in organic cation transport	IMP IMP: 通过突变表型推断	23864433	GOA
involved in prostaglandin transport	IDA IDA: 通过直接分析推断	11907186	GOA
involved in putrescine transport	IDA IDA: 通过直接分析推断	21128598	GOA
involved in serotonin transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in serotonin uptake	IDA IDA: 通过直接分析推断	9687576	GOA
involved in thiamine transmembrane transport	IDA IDA: 通过直接分析推断	24961373	GOA
involved in xenobiotic transport	IDA IDA: 通过直接分析推断	9687576	GOA
involved in xenobiotic transport	IMP IMP: 通过突变表型推断	20477935	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	15817714	GOA
located in basal plasma membrane	IDA IDA: 通过直接分析推断	35307651	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	23137377	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A2 蛋白结构

Sugar_tr

0
100
200
300
400
500
555 a.a.

蛋白主名

其他名称

solute carrier family 22 member 2

organic cation transporter 2

关联疾病

疾病名称

别名

Carnitine Deficiency, Systemic Primary

Carnitine Uptake Defect	Renal Carnitine Transport Defect
Systemic Primary Carnitine Deficiency	CDSP
Systemic Carnitine Deficiency	Carnitine Transporter Deficiency
Cud	Primary Carnitine Deficiency
Carnitine Uptake Deficiency	Carnitine Deficiency, Systemic, Due To Defect In Renal Reabsorption Of Carnitine
Carnitine Deficiency, Primary	Systemic Primary Carnitine Deficiency Disease
Deficiency Of Plasma-Membrane Carnitine Transporter	Scd
Carnitine Transporter, Plasma-Membrane, Deficiency Of	Carnitine Transport Defect
Carnitine Plasma-Membrane Transporter Deficiency	Carnitine Transporter Defect
Spcd

Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8	Iddm8
Insulin-Dependent Diabetes Mellitus 8	T1D8
Insulin-Dependent Diabetes Mellitus-8

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Fanconi-Like Syndrome

Fanconi Like Syndrome

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Cystoisosporiasis

Isosporiasis	Infection By Isospora Belli And Isospora Hominis
Isosporosis	Infection By Isospora Belli Or Isospora Hominis
Isospora Belli Or Hominis Infection	Coccidial Infestation
Coccidiosis	Coccidial Dysentery
Intestinal Coccidiosis Nos

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13072	SLC22A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC22A2	MGD	MGI:1335072
Felis catus	SLC22A2	VGNC	VGNC:99773
Rattus norvegicus	SLC22A2	RGD	RGD:61936
Bos taurus	SLC22A2	VGNC	VGNC:53805
Canis familiaris	SLC22A2	VGNC	VGNC:53985
Macaca mulatta	SLC22A2	VGNC	VGNC:83465
Others	SLC22A2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC22A2 - solute carrier family 22 member 2 Gene

关于 SLC22A2

功能概要

SLC22A2 基因产物(1)

SLC22A2 蛋白结构

关联疾病

直系同源

热门区域

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SLC22A2 - solute carrier family 22 member 2 Gene

关于 SLC22A2

功能概要

SLC22A2 基因产物(1)

SLC22A2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z