SIGLEC1 - sialic acid binding Ig like lectin 1 Gene

中文名称：唾液酸结合 Ig 样凝集素 1

种属: Homo sapiens

同用名: SN; CD169; SIGLEC-1

基因 ID: 6614 | 基因类型: protein coding

关于 SIGLEC1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,686,970-3,712,600 (from NCBI)

This gene has 2 transcripts (splice variants), 135 orthologues and 16 paralogues. Broad expression in placenta (RPKM 8.2), spleen (RPKM 6.4) and 20 other tissues.

功能概要

该基因编码免疫球蛋白超家族的一个成员。编码的蛋白质是一种凝集素样粘附分子，它以唾液酸依赖性方式结合细胞表面的糖缀合物配体。它是仅由巨噬细胞亚群表达的 I 型跨膜蛋白，参与介导细胞间相互作用。该蛋白在多种人类疾病中起着重要作用，细菌和病毒感染已被证明可增强 SARS-CoV-2 感染。[RefSeq 提供，2021 年 12 月]

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and Bacterial and viral infections has been shown to enhance SARS-CoV-2 Infection. [provided by RefSeq, Dec 2021]

SIGLEC1 基因产物(2)

mRNA	Protein	Name
NM_001367089.1	NP_001354018.1	sialoadhesin isoform 2 precursor
NM_023068.4	NP_075556.1	sialoadhesin isoform 1 precursor

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of type I interferon production	IDA IDA: 通过直接分析推断	26358190	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in plasma membrane	IDA IDA: 通过直接分析推断	28129379	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIGLEC1 蛋白结构

V-set

C2-set_2

Ig_2

I-set

Ig_2

I-set

Ig_2

0
300
600
900
1200
1500
1709 a.a.

蛋白主名

其他名称

sialoadhesin

sialic acid binding Ig-like lectin 1, sialoadhesin

重组 SIGLEC1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78743	Siglec-1/CD169 Protein, Human (HEK293, His)	Q9BZZ2-1 (S20-Q1641)	≥95%

SIGLEC1 抗体

目录号	产品名	应用	反应物种
HY-P81515	CD169 Antibody (YA1260)	IHC-P	Human
HY-P81548	CD169 Antibody (YA1293)	WB, FC	Human, Mouse
HY-P84780	CD169 Antibody (YA4477)	ICC/IF, FC, ELISA	Human

关联疾病

疾病名称

别名

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12897	SIGLEC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18016	Siglec1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24489	Siglec1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SIGLEC1	VGNC	VGNC:34617
Rattus norvegicus	SIGLEC1	RGD	RGD:1311953
Macaca mulatta	SIGLEC1	VGNC	VGNC:77220
Felis catus	SIGLEC1	VGNC	VGNC:65141
Mus musculus	SIGLEC1	MGD	MGI:1921304
Canis familiaris	SIGLEC1	VGNC	VGNC:46168
Macaca fascicularis	SIGLEC1	NCBI	NCBI:102139468
Others	SIGLEC1	NCBI

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