2. Gene
  3. Pkp2 - plakophilin 2 Gene

Pkp2 - plakophilin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pkp2l; 1200008D14Rik; 1200012P04Rik

基因 ID: 67451 | 基因类型: protein coding

关于 Pkp2

功能概要

Predicted to enable several functions, including alpha-catenin binding activity; Cadherin binding activity; and protein kinase C binding activity. Acts upstream of or within cell-cell adhesion and heart development. Located in desmosome; intercalated disc; and intermediate filament. Is expressed in brain; cardiac muscle tissue; and telencephalon. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pkp2 基因产物(1)

mRNA Protein Name
NM_026163.2 NP_080439.1 plakophilin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17535849 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell-cell adhesion IMP
IMP: 通过突变表型推断
15479741 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
15479741 MGI
involved in maintenance of protein localization at cell tip IMP
IMP: 通过突变表型推断
35959657 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
21296051 MGI
located in cell-cell junction IMP
IMP: 通过突变表型推断
15479741 MGI
located in desmosome IDA
IDA: 通过直接分析推断
9864371 MGI
located in intercalated disc IDA
IDA: 通过直接分析推断
17535849 MGI
located in intermediate filament IDA
IDA: 通过直接分析推断
16917092 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

plakophilin-2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10612 PKP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20326 Pkp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26834 Pkp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pkp2 NCBI NCBI:5318
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