2. Gene
  3. Abcg8 - ATP binding cassette subfamily G member 8 Gene

Abcg8 - ATP binding cassette subfamily G member 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: sterolin-2; 1300003C16Rik

基因 ID: 67470 | 基因类型: protein coding

关于 Abcg8

功能概要

Enables protein heterodimerization activity. Contributes to Cholesterol transfer activity. Involved in Cholesterol efflux and excretion. Acts upstream of or within Cholesterol homeostasis and phospholipid transport. Located in apical plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Is expressed in several structures, including Peyer's patch; alimentary system; brain; liver and biliary system; and thymus. Used to study sitosterolemia. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcg8 基因产物(3)

mRNA Protein Name
NM_001286005.1 NP_001272934.1 ATP-binding cassette sub-family G member 8 isoform 2
NM_001347418.1 NP_001334347.1 ATP-binding cassette sub-family G member 8 isoform 3
NM_026180.3 NP_080456.1 ATP-binding cassette sub-family G member 8 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to cholesterol transfer activity IMP
IMP: 通过突变表型推断
14504269 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12208867 MGI
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
12208867 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol efflux IMP
IMP: 通过突变表型推断
14504269 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: 通过突变表型推断
15040800 MGI
acts upstream of or within phospholipid transport IMP
IMP: 通过突变表型推断
15040800 MGI
acts upstream of or within sterol homeostasis IMP
IMP: 通过突变表型推断
15040800 MGI
involved in sterol transport IDA
IDA: 通过直接分析推断
16867993 MGI
acts upstream of or within sterol transport IMP
IMP: 通过突变表型推断
15040800 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12208867 MGI
located in apical plasma membrane IMP
IMP: 通过突变表型推断
14504269 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12208867 MGI
part of receptor complex IDA
IDA: 通过直接分析推断
14504269 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ATP-binding cassette sub-family G member 8

ATP-binding cassette, sub-family G (WHITE), member 8

sterolin 2

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0288 Lycorine 99.98% 否
HY-RS00082 ABCG8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18052 Abcg8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24526 Abcg8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abcg8 NCBI NCBI:64241
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