Rnf168 - ring finger protein 168 Gene

种属: Rattus norvegicus

关于 Rnf168

功能概要

Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within cellular response to UV and regulation of protein localization. Predicted to be located in cytosol; nucleoplasm; and site of double-strand break. Predicted to be part of DNA repair complex and ubiquitin Ligase complex. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168). [provided by Alliance of Genome Resources, Apr 2022]