TRB - T cell receptor beta locus Gene

中文名称：细胞受体β位点

种属: Homo sapiens

同用名: TCRB; TRB@

基因 ID: 6957 | 基因类型: protein coding

关于 TRB

功能概要

细胞受体识别已被加工成小肽并与抗原呈递细胞 (APC) 表面的主要组织相容性复合体 (MHC) 分子结合的外来抗原。每个 T 细胞受体都是一个二聚体，由一条α链和一条β链或一条δ链和一条γ链组成。在单个细胞中，T 细胞受体基因座以 delta、gamma、beta 和 alpha 的顺序重新排列和表达。如果 delta 和 gamma 重排都产生功能链，则细胞表达 delta 和 gamma。如果不是，细胞会继续重新排列 beta 和 alpha 位点。该区域代表 T 细胞受体 β 基因座的种系组织。 Beta 基因座包括 V (可变) 、J (连接) 、多样性 (D) 和 C (恒定) 片段。在 T 细胞发育过程中，β 链是通过 DNA 水平的重组事件合成的，将 D 片段与 J 片段连接起来；然后将 V 片段连接到 DJ 基因。 C 段后来通过在 RNA 水平上的剪接连接。许多不同的 V 区段与几个 J 区段的重组提供了广泛的抗原识别。额外的多样性是通过连接多样性获得的，连接多样性是由末端脱氧核苷酸转移酶随机添加核苷酸引起的。已知 β 基因座的几个 V 区段和一个 J 区段不能编码蛋白质，被认为是假基因。 β 基因座还包括八个胰蛋白酶原基因，其中三个编码功能蛋白，另外五个是假基因。涉及 T 细胞受体 β 位点的染色体异常与 T 细胞淋巴瘤有关。[RefSeq 提供，2008 年 7 月]

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables signaling receptor activity	IDA IDA: 通过直接分析推断	31959982	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: 通过直接分析推断	31959982	GOA
involved in detection of tumor cell	IDA IDA: 通过直接分析推断	31959982	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of alpha-beta T cell receptor complex	IDA IDA: 通过直接分析推断	31959982	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

关联疾病

疾病名称

别名

Trypsinogen Deficiency

Pancreatic Trypsinogen Deficiency

Vitamin D-Dependent Rickets, Type 2a

Hvdrr	Generalized Resistance To 1,25-Dihydroxyvitamin D
Hypocalcemic Vitamin D-Resistant Rickets	VDDR2A
Rickets, Hereditary Vitamin D-Resistant	Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol
Pddr Iia	Rickets-Alopecia Syndrome
Rickets, Vitamin D-Resistant, Type Iia	Vitamin D-Dependent Rickets Type 2a
Vitamin D-Dependent Rickets, Type 2	Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia
Generalized 1,25-Dihydroxyvitamin D	Pseudovitamin D-Deficiency, Type Iia
Hereditary Vitamin D-Resistant Rickets	Vddr Ii
Vdrr Ii	Vitamin D-Dependent Rickets Type Ii
Vitamin D-Resistant Rickets Type Ii	Rickets Vitamin D-Dependent 2a
Pseudovitamin D-Deficiency Type Iia	Rickets Hereditary Vitamin D-Resistant
Type Iia Rickets	Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia
Vitamin D-Dependent Rickets, Type Ii	Familial Hypophosphatemic Rickets
Hypophosphatemic Rickets, X-Linked Dominant

Prss1-Related Hereditary Pancreatitis

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Granulomatous Slack Skin Disease

Granulomatous Slack Skin

B-Cell Expansion With Nfkb And T-Cell Anergy

Benta Disease	BENTA
B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease	Persistent Polyclonal B-Cell Lymphocytosis
Lymphocytosis

T-Cell Large Granular Lymphocyte Leukemia

Large Granular Lymphocytic Leukemia	Proliferation Of Large Granular Lymphocytes
T-Lgl	T-Cell Lgl Leukemia
Large Granular Lymphocytic Leukaemia	T-Cell Large Granular Lymphocyte Leukaemia
Large Cell Granular Lymphogenous Leukemia	T-Lgl Leukemia
Leukemia Lymphocytic Large Granular	Leukemia, Large Granular Lymphocytic

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Reticulosarcoma

Histiocytic Lymphoma	Large-Cell Lymphomas
Lymphoma, Large-Cell	Lymphoma Large Cell
Diffuse Large B-Cell Lymphoma	Histiocytic Sarcoma

Pleurisy

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms	Relapsing Remitting Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting	Rrms
Multiple Sclerosis Relapsing-Remitting

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma	Cutaneous T Cell Lymphoma
Lymphoma, T-Cell, Cutaneous	Ctcl
Lymphoma T-Cell Cutaneous

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-Y1309	1-Naphthol		99.96%	否
HY-120793	CMC2.24		97.48%	否
HY-RS14501	THRB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS14997	TRB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-Y1309S	1-Naphthol-d8		/	否
HY-RS20688	Aatf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-Y1309S1	1-Naphthol-d7		99.44%	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TRB	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRB - T cell receptor beta locus Gene

关于 TRB

功能概要

关联疾病

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TRB - T cell receptor beta locus Gene

关于 TRB

功能概要

关联疾病

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