TFAP2B - transcription factor AP-2 beta Gene

中文名称：转录因子 AP-2 β

种属: Homo sapiens

同用名: PDA2; AP-2B; AP2-B; AP-2beta

基因 ID: 7021 | 基因类型: protein coding

关于 TFAP2B

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:50,818,355-50,847,619 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 4 paralogues and is associated with 5 phenotypes. Biased expression in kidney (RPKM 3.0), skin (RPKM 2.7) and 4 other tissues.

功能概要

该基因编码 AP-2 转录因子家族的成员。 AP-2 蛋白与其他 AP-2 家族成员形成同二聚体或异二聚体，并结合特定的 DNA 序列。它们被认为在胚胎发育过程中刺激细胞增殖并抑制特定细胞类型的终末分化。特定 AP-2 家族成员的表达模式和对不同启动子的结合亲和力不同。这种蛋白质既可以作为转录激活因子，也可以作为抑制因子。该基因的突变导致常染色体显性 Char 综合征，表明该基因在神经嵴细胞衍生物的分化中起作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with Other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

TFAP2B 基因产物(1)

mRNA	Protein	Name
NM_003221.4	NP_003212.2	transcription factor AP-2-beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7559606	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	11505339	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7555706	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	7555706	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	16373396	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7555706	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	11505339	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	11505339	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	11505339	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in fat cell differentiation	IEP IEP: 通过表达模式推断	16373396	GOA
involved in glucose metabolic process	IMP IMP: 通过突变表型推断	15940393	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	20607706	GOA
acts upstream of negative effect negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	17525748	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	20607706	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7559606	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11505339	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	16373396	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	17525748	GOA
involved in positive regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	20607706	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7555706	GOA
involved in regulation of cell differentiation	IDA IDA: 通过直接分析推断	20607706	GOA
involved in regulation of insulin secretion	IMP IMP: 通过突变表型推断	15940393	GOA
involved in retina layer formation	IEP IEP: 通过表达模式推断	20607706	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	20607706	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TFAP2B 蛋白结构

TF_AP-2

0
100
200
300
400
460 a.a.

蛋白主名

其他名称

transcription factor AP-2-beta

AP2-beta

TFAP2B 抗体

目录号	产品名	应用	反应物种
HY-P84697	TFAP2B Antibody (YA4394)	WB, FC, ELISA	Human

关联疾病

疾病名称

别名

Char Syndrome

Patent Ductus Arteriosus With Facial Dysmorphism And Abnormal Fifth Digits

CHAR

Patent Ductus Arteriosus 2

PDA2

Familial Patent Arterial Duct

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction	Chronic Intestinal Pseudo-Obstruction
Cipo	Neuronal Intestinal Dysplasia
Hollow Visceral Myopathy	Familial Visceral Neuropathy
Paralytic Ileus	Intestinal Pseudoobstruction
Chronic Idiopathic Intestinal Pseudo-Obstruction	Ciip
Congenital Short Bowel Syndrome	Enteric Neuropathy
Familial Visceral Myopathy	Ipo
Pseudo-Obstruction Of Intestine	Pseudointestinal Obstruction Syndrome
Pseudoobstructive Syndrome	Congenital Idiopathic Intestinal Pseudoobstruction
Visceral Myopathy, Familial

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Orbit Embryonal Rhabdomyosarcoma

Embryonal Rhabdomyosarcoma Of The Orbit

Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome	BOFS
Bof Syndrome	Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome
Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome	Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging
Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging	Bofs Syndrome
Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Hyaline Fibromatosis Syndrome

Juvenile Hyaline Fibromatosis	Inherited Systemic Hyalinosis
Puretic Syndrome	Infantile Systemic Hyalinosis
HFS	Hyalinosis, Systemic
Systemic Hyalinosis	Molluscum Fibrosum
Murray Syndrome	Murray-Puretic-Drescher Syndrome
Ish	Jhf
Fibromatosis, Juvenile Hyaline	Hyalinosis, Systemic Infantile
Fibromatosis, Hyaline Syndrome	Neurofibromatosis 1

Orbit Rhabdomyosarcoma

Rhabdomyosarcoma Of The Orbit

Rhabdomyosarcoma Of Orbit

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Atrial Heart Septal Defect

Atrial Septal Defect	Atrial Septal Defects
Atrioseptal Defect	Auricular Septal Defect
Congenital Atrial Septal Defect	Interatrial Septal Defect
Interauricular Septal Defect	Heart Septal Defects, Atrial
Septal Defect, Atrial

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14409	TFAP2B Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TFAP2B	VGNC	VGNC:66109
Mus musculus	TFAP2B	MGD	MGI:104672
Rattus norvegicus	TFAP2B	RGD	RGD:1306321
Canis familiaris	TFAP2B	VGNC	VGNC:47284
Bos taurus	TFAP2B	VGNC	VGNC:35777
Macaca mulatta	TFAP2B	VGNC	VGNC:78321

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TFAP2B - transcription factor AP-2 beta Gene

关于 TFAP2B

功能概要

TFAP2B 基因产物(1)

TFAP2B 蛋白结构

TFAP2B 抗体

关联疾病

直系同源

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TFAP2B - transcription factor AP-2 beta Gene

关于 TFAP2B

功能概要

TFAP2B 基因产物(1)

TFAP2B 蛋白结构

TFAP2B 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

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