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  3. TFDP2 - transcription factor Dp-2 Gene

TFDP2 - transcription factor Dp-2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转录因子 DP-2

种属: Homo sapiens

同用名: DP2

基因 ID: 7029 | 基因类型: protein coding

关于 TFDP2

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,944,428-142,149,544 (from NCBI)

This gene has 24 transcripts (splice variants), 159 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues.

功能概要

该基因是转录因子 DP 家族的成员。编码的蛋白质与 E2F 转录因子形成异二聚体，导致细胞周期调节基因的转录激活。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 5 月]

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

TFDP2 基因产物(14)

mRNA Protein Name
NM_001178138.2 NP_001171609.1 transcription factor Dp-2 isoform 1
NM_001178139.2 NP_001171610.1 transcription factor Dp-2 isoform 2
NM_001178140.2 NP_001171611.1 transcription factor Dp-2 isoform 3
NM_001178141.2 NP_001171612.1 transcription factor Dp-2 isoform 4
NM_001178142.2 NP_001171613.1 transcription factor Dp-2 isoform 5
NM_001375756.1 NP_001362685.1 transcription factor Dp-2 isoform 6
NM_001375773.1 NP_001362702.1 transcription factor Dp-2 isoform 7
NM_001375774.1 NP_001362703.1 transcription factor Dp-2 isoform 8
NM_001375775.1 NP_001362704.1 transcription factor Dp-2 isoform 9
NM_001375776.1 NP_001362705.1 transcription factor Dp-2 isoform 1
NM_001375778.1 NP_001362707.1 transcription factor Dp-2 isoform 6
NM_001375779.1 NP_001362708.1 transcription factor Dp-2 isoform 10
NM_001375780.1 NP_001362709.1 transcription factor Dp-2 isoform 10
NM_006286.5 NP_006277.1 transcription factor Dp-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
7739537 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7739537 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16061792 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
16360038 GOA
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
7784053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20176812 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7739537 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
7739537 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TFDP2 蛋白结构

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (127 - 208)

DP

DP: Transcription factor DP (215 - 355)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
蛋白主名 其他名称

transcription factor Dp-2

transcription factor Dp-2 (E2F dimerization partner 2)

关联疾病

疾病名称 别名
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14418 TFDP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS22857 Tfdp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS29371 Tfdp2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TFDP2 VGNC VGNC:66115
Canis familiaris TFDP2 VGNC VGNC:47292
Mus musculus TFDP2 MGD MGI:107167
Bos taurus TFDP2 VGNC VGNC:35786
Rattus norvegicus TFDP2 RGD RGD:1305814
Macaca mulatta TFDP2 VGNC VGNC:78324
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