P2ry12 - purinergic receptor P2Y, G-protein coupled 12 Gene

中文名称：嘌呤能受体 P2 Y，G 蛋白偶联 12

种属: Mus musculus

同用名: P2Y12; 2900079B22Rik; 4921504D23Rik

关于 P2ry12

功能概要

该基因编码的蛋白可启动 G 蛋白偶联 ADP 受体活性和 G 蛋白偶联腺苷受体活性。参与多个过程，包括细胞对 ATP 的反应；调节小胶质细胞迁移；和底物依赖性细胞迁移，细胞延伸。作用于多个过程的上游或内部，包括腺苷酸环化酶调节 G 蛋白偶联受体信号通路；血小板活化；和离子传输的正调节。位于细胞体膜和细胞投射膜。表达于中枢神经系统和大脑皮层。用于研究血小板型出血性疾病 8. 该基因的人类直系同源物与哮喘有关；脑血管疾病;外周动脉疾病；血小板型出血性疾病 8；和 2 型糖尿病。与人 P2RY12（嘌呤能受体 P2Y12）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled ADP receptor activity and G protein-coupled Adenosine Receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]