2. Gene
  3. Sfpq - splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Gene

Sfpq - splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PSF; REP1; Gm12940; D4Ertd314e; 1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik

基因 ID: 71514 | 基因类型: protein coding

关于 Sfpq

功能概要

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including dendritic transport of messenger ribonucleoprotein complex; histone H3 deacetylation; and negative regulation of circadian rhythm. Acts upstream of or within cellular response to DNA damage stimulus; chromosome organization; and positive regulation of sister chromatid cohesion. Located in paraspeckles. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; lung mesenchyme; sensory organ; and testis. Orthologous to human SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Apr 2022]

Sfpq 基因产物(1)

mRNA Protein Name
NM_023603.3 NP_076092.1 splicing factor, proline- and glutamine-rich
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
19389484 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18495661 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
21680841 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
20813759 MGI
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
21680841 MGI
acts upstream of or within chromosome organization IMP
IMP: 通过突变表型推断
20813759 MGI
involved in dendritic transport of messenger ribonucleoprotein complex IDA
IDA: 通过直接分析推断
15312650 MGI
involved in dendritic transport of messenger ribonucleoprotein complex IMP
IMP: 通过突变表型推断
15312650 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
22966205 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
21680841 MGI
involved in negative regulation of circadian rhythm IMP
IMP: 通过突变表型推断
21680841 MGI
acts upstream of or within positive regulation of sister chromatid cohesion IMP
IMP: 通过突变表型推断
20813759 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: 通过突变表型推断
20813759 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
22966205 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
19389484 MGI
located in paraspeckles IDA
IDA: 通过直接分析推断
21444682 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

splicing factor, proline- and glutamine-rich

DNA-binding p52/p100 complex, 100 kDa subunit

PTB-associated splicing factor

polypyrimidine tract-binding protein-associated-splicing factor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12770 SFPQ Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22321 Sfpq Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28843 Sfpq Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sfpq NCBI NCBI:6421
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