1. Gene
  2. Cul4b - cullin 4B Gene

Cul4b - cullin 4B Gene

种属: Mus musculus

同用名: CUL-4B; mKIAA0695; 2700050M05Rik

基因 ID: 72584 | 基因类型: protein coding

关于 Cul4b

功能概要

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to damaged DNA binding activity. Involved in ribosome biogenesis. Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and positive regulation of protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4B-RING E3 ubiquitin Ligase complex. Is expressed in brain and liver. Used to study intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Apr 2022]

Cul4b 基因产物(2)

mRNA Protein Name
NM_001110142.1 NP_001103612.1 cullin-4B
NM_028288.5 NP_082564.3 cullin-4B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
30442713 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte differentiation IMP
IMP: 通过突变表型推断
26025376 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
26025376 MGI
acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
19056892 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
18602923 MGI
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
35197566 MGI
involved in ribosome biogenesis IMP
IMP: 通过突变表型推断
26711351 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
35197566 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4A-RING E3 ubiquitin ligase complex EXP
EXP: 通过实验结果推断
22118460 MGI
part of Cul4B-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
35197566 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

cullin-4B

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cul4b NCBI NCBI:8450