TUB - TUB bipartite transcription factor Gene

中文名称：TUB 双转录因子

种属: Homo sapiens

同用名: rd5; RDOB

基因 ID: 7275 | 基因类型: protein coding

关于 TUB

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,019,059-8,106,243 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues, 5 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 18.8), endometrium (RPKM 10.0) and 21 other tissues.

功能概要

该基因编码二分转录因子 Tubby 家族的一个成员。编码的蛋白质可能在肥胖和感觉神经退化中起作用。已确定小鼠中一种类似蛋白质的晶体结构，它作为膜结合转录调节剂发挥作用，响应磷酸肌醇水解而转移至细胞核。已经为该基因鉴定了编码不同亚型的两个转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

TUB 基因产物(2)

mRNA	Protein	Name
NM_003320.5	NP_003311.2	tubby protein homolog isoform a
NM_177972.3	NP_813977.1	tubby protein homolog isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor binding	IDA IDA: 通过直接分析推断	28154160	GOA
enables intraciliary transport particle A binding	IDA IDA: 通过直接分析推断	28154160	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	20889716	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within intraciliary transport	IDA IDA: 通过直接分析推断	28154160	GOA
involved in positive regulation of phagocytosis	IDA IDA: 通过直接分析推断	19837063	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cilium	IDA IDA: 通过直接分析推断	28154160	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	28154160	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28154160	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TUB 蛋白结构

Tub

0
100
200
300
400
506 a.a.

蛋白主名

其他名称

tubby protein homolog

tubby bipartite transcription factor

重组 TUB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P701073	Tubby Protein, Human (His)	P50607-1 (M1-E506)	≥95%

TUB 抗体

目录号	产品名	应用	反应物种
HY-P87122	TUB Antibody (YA6815)	WB, IHC-P, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Retinal Dystrophy And Obesity

RDOB	Dystrophy, Retinal, And Obesity

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Coffin-Siris Syndrome 2

CSS2	Mrd14
Mental Retardation, Autosomal Dominant 14	Autosomal Dominant Mental Retardation 14
Coffin-Siris Syndrome, Type 2

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Multidrug-Resistant Tuberculosis

Tuberculosis, Multidrug-Resistant

Tuberculosis Multidrug-Resistant

Bagassosis

Sugar Cane Worker Pneumonitis	Bagasse Workers' Lung
Bagasse Disease	Bagasse Disease Or Pneumonitis
Bagasse Workers' Disease	Fibrosis Of Lung With Bagassosis
Sugar Cane Workers' Hypersensitivity Pneumonitis	Bagasse Pneumonitis
Hypersensitivity Pneumonitis With Bagassosis

Tinea Nigra

Microsporosis Nigra	Infection By Cladosporium Werneckii
Keratomycosis Nigricans	Tinea Palmaris Nigra
Keratomycosis Nigricans Palmaris

Night Blindness

Nyctalopia

Cardiomyopathy, Familial Hypertrophic, 16

Hypertrophic Cardiomyopathy 16	CMH16
Cardiomyopathy, Hypertrophic, 16	Cardiomyopathy Familial Hypertrophic 16
Cardiomyopathy, Familial Hypertrophic 16	Cardiomyopathy, Hypertrophic, Familial, Type 16

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Cardiomyopathy, Familial Hypertrophic, 18

Hypertrophic Cardiomyopathy 18	CMH18
Cardiomyopathy, Hypertrophic, 18	Cardiomyopathy Familial Hypertrophic 18
Cardiomyopathy, Familial Hypertrophic 18	Cardiomyopathy, Hypertrophic, Familial, Type 18

Lip Cancer

Malignant Neoplasm Of Lip	Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Tumour Of Lip	Lip Neoplasms
Malignant Neoplasm Of Commissure Of Lip	Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower
Malignant Neoplasm Of Labial Commissure Of Lip	Malignant Neoplasm Of Lip, External
Malignant Neoplasm Of Lip, Inner Aspect	Malignant Neoplasm Of Lip, Vermilion Border
Malignant Neoplasm Of Lower Lip, Buccal Aspect	Malignant Neoplasm Of Lower Lip, Inner Aspect
Malignant Neoplasm Of Lower Lip, Mucosa	Malignant Neoplasm Of Lower Lip, Oral Aspect
Malignant Neoplasm Of Other Sites Of Lip	Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Tumor Of Commissure Of Lip	Malignant Tumor Of Labial Mucosa
Malignant Tumor Of Lip	Malignant Tumor Of Lower Labial Mucosa
Malignant Tumor Of The Lip	Malignant Tumour Of Labial Commissure
Cancer Of Lip	Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip
Upper Lip Cancer	Lower Lip Cancer
Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip	Primary Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Neoplasm Of Lipstick Area Of Upper Lip	Malignant Neoplasm Of Upper Lip Nos
Malignant Neoplasm Of Vermilion Border Of Upper Lip	Malignant Neoplasm Of Lipstick Area Of Lower Lip
Malignant Neoplasm Of Lower Lip Nos	Malignant Neoplasm Of Vermilion Border Of Lower Lip
Malignant Neoplasm Of Vermilion Border Nos	Malignant Neoplasm Of Buccal Aspect Of Upper Lip
Malignant Neoplasm Of Frenulum Of Upper Lip	Malignant Neoplasm Of Mucosa Of Upper Lip
Malignant Neoplasm Of Oral Aspect Of Upper Lip	Malignant Neoplasm Of Buccal Aspect Of Lower Lip
Malignant Neoplasm Of Frenulum Of Lower Lip	Malignant Neoplasm Of Mucosa Of Lower Lip
Malignant Neoplasm Of Oral Aspect Of Lower Lip	Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower	Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower
Primary Malignant Neoplasm Of Commissure Of Lip	Primary Malignant Neoplasm Of Lip
Malignant Neoplasm Of Lip, Unspecified

Bird Fancier'S Lung

Bird Fancier Lung	Pigeon Breeder'S Lung
Avian Hypersensitivity Pneumonitis	Bird Breeder'S Lung
Bird-Fancier'S Lung	Bird-Fanciers' Lung
Poultry Worker'S Lung	Pigeon-Breeder Lung Disease
Pigeon Breeders Lung	Avian Protein Hypersensitivity
Bird Breeders' Disease	Bird Breeders' Lung
Bird Fanciers' Lung	Bird Fanciers' Disease
Bfl - [Bird Fancier Lung]	Fanciers' Disease
Fanciers' Lung

Cardiomyopathy, Familial Hypertrophic, 17

Hypertrophic Cardiomyopathy 17	CMH17
Cardiomyopathy, Hypertrophic, 17	Cardiomyopathy Familial Hypertrophic 17
Cardiomyopathy, Familial Hypertrophic 17	Cardiomyopathy, Hypertrophic, Familial, Type 17

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13250	Silvestrol aglycone		99.84%	否
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	否
HY-148450	eIF4A3-IN-16	Inhibitor	99.96%	否
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	否
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	否
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	否
HY-148447	eIF4A3-IN-13	Inhibitor	99.92%	否
HY-148449	eIF4A3-IN-15	Inhibitor	/	否
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	否
HY-177413	Tub114	Inhibitor	/	否
HY-RS15244	TUB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-168326	Antiproliferative agent-64	Inhibitor	/	否
HY-RS17577	Tub Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24037	Tub Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TUB	VGNC	VGNC:78672
Bos taurus	TUB	VGNC	VGNC:36503
Mus musculus	TUB	MGD	MGI:2651573
Rattus norvegicus	TUB	RGD	RGD:3918
Felis catus	TUB	VGNC	VGNC:66696
Canis familiaris	TUB	VGNC	VGNC:47986
Others	TUB	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TUB - TUB bipartite transcription factor Gene

关于 TUB

功能概要

TUB 基因产物(2)

TUB 蛋白结构

重组 TUB 蛋白

TUB 抗体

关联疾病

直系同源

热门区域

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TUB - TUB bipartite transcription factor Gene

关于 TUB

功能概要

TUB 基因产物(2)

TUB 蛋白结构

重组 TUB 蛋白

TUB 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z