UBE2V1 - ubiquitin conjugating enzyme E2 V1 Gene

中文名称：泛素结合酶 E2 V1

种属: Homo sapiens

同用名: CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1

关于 UBE2V1

功能概要

泛素结合 E2 酶变体蛋白构成 E2 蛋白家族中的一个独特亚家族。它们与其他泛素结合酶具有序列相似性，但缺少对 E2 的催化活性至关重要的保守半胱氨酸残基。该基因编码的蛋白质位于细胞核内，可引起人类 FOS 原癌基因的转录激活。它被认为通过改变细胞周期行为参与分化的控制。已经描述了该基因编码多种同种型的选择性剪接转录物变体，并且已经鉴定了该基因的多个假基因。该基因和相邻上游基因的共转录产生一个罕见的转录本 (Kua-UEV) ，它编码一种融合蛋白，该融合蛋白由与每个单独基因产物共享同一性的序列组成。[RefSeq 提供，2012 年 4 月]

Ubiquitin-conjugating E2 Enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]