UCN - urocortin Gene

中文名称：尿皮质素

种属: Homo sapiens

同用名: UI; UCN1; UROC

基因 ID: 7349 | 基因类型: protein coding

关于 UCN

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,307,400-27,308,445 (from NCBI)

This gene has 1 transcript (splice variant), 153 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

该基因编码 sauvagine/促肾上腺皮质激素释放因子/urotensin I 家族的成员。编码的前原蛋白经过蛋白水解处理以生成成熟肽，成熟肽是促肾上腺皮质激素释放因子受体 1 和促肾上腺皮质激素释放因子受体 2 的内源性配体。在大脑中，这种肽可能与压力对食欲的影响有关。这种肽也可能在情绪障碍、神经变性和骨骼系统疾病中发挥作用。尽管基因家族名称相似，但该基因的产物与 urotensin-2 没有序列相似性。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]

UCN 基因产物(1)

mRNA	Protein	Name
NM_003353.4	NP_003344.1	urocortin preproprotein

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18234674	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of corticotropin secretion	IDA IDA: 通过直接分析推断	11329063	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UCN 蛋白结构

CRF

0
100
124 a.a.

蛋白主名

其他名称

urocortin

prepro-urocortin

关联疾病

疾病名称

别名

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Colitis

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Deafness, Aminoglycoside-Induced

Streptomycin Ototoxicity	Deafness, Mitochondrial, Modifier Of
Aminoglycoside-Induced Deafness	Deafness, Streptomycin-Induced
Streptomycin-Induced Deafness	DFNI

Deafness, Autosomal Recessive 40

DFNB40	Autosomal Recessive Nonsyndromic Deafness 40
Autosomal Recessive Deafness 40

Deafness, Autosomal Recessive 55

DFNB55	Autosomal Recessive Nonsyndromic Deafness 55
Autosomal Recessive Deafness 55

Drug-Induced Hearing Loss

Drug Induced Hearing Loss

Dicrocoeliasis

Disease Due To Dicrocoeliidae	Lancet Fluke Infection
Dicroceliosis	Lancet Fluke Disease
Lancet Fluke Infestation

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-13661	7-Hydroxystaurosporine		/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1858A	Urocortin III, mouse TFA	Activator	95.93%	否
HY-105416	Calphostin C	Inhibitor	99.9%	否
HY-108262	UCN-02	Inhibitor	≥98.0%	否
HY-P1858	Urocortin III, mouse	Activator	/	否
HY-RS15407	UCN Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS15408	UCN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS15409	UCN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17732	Ucn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21451	Ucn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24197	Ucn Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27969	Ucn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UCN	MGD	MGI:1276123
Canis familiaris	UCN	VGNC	VGNC:48108
Rattus norvegicus	UCN	RGD	RGD:3929
Macaca mulatta	UCN	VGNC	VGNC:78707
Bos taurus	UCN	VGNC	VGNC:36637
Others	UCN	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UCN - urocortin Gene

关于 UCN

功能概要

UCN 基因产物(1)

UCN 蛋白结构

关联疾病

直系同源

热门区域

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UCN - urocortin Gene

关于 UCN

功能概要

UCN 基因产物(1)

UCN 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z