YWHAB - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Gene

中文名称：酪氨酸 3-单加氧酶/色氨酸 5-单加氧酶激活蛋白 β

种属: Homo sapiens

同用名: HS1; GW128; YWHAA; KCIP-1; HEL-S-1

基因 ID: 7529 | 基因类型: protein coding

关于 YWHAB

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,885,705-44,908,532 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues.

功能概要

该基因编码属于 14-3-3 蛋白家族的一种蛋白，该蛋白的成员通过与含磷酸丝氨酸的蛋白结合来介导信号转导。这种高度保守的蛋白质家族存在于植物和哺乳动物中。编码的蛋白质已被证明与 RAF1 和 CDC25 磷酸酶相互作用，表明它可能在连接促有丝分裂信号和细胞周期机制方面发挥作用。已经为该基因鉴定了编码相同蛋白质的两个转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

YWHAB 基因产物(2)

mRNA	Protein	Name
NM_003404.5	NP_003395.1	2014/3/3 protein beta/alpha
NM_139323.4	NP_647539.1	2014/3/3 protein beta/alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	17255105	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	10869435	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17085597	GOA
enables phosphoprotein binding	IPI IPI: 通过物理相互作用推断	10869435	GOA
enables phosphoserine residue binding	IPI IPI: 通过物理相互作用推断	10869435	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7644510	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	11984006	GOA
enables protein kinase inhibitor activity	IDA IDA: 通过直接分析推断	11555644	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoplasmic sequestering of protein	IDA IDA: 通过直接分析推断	10869435	GOA
involved in negative regulation of G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	21224381	GOA
involved in positive regulation of catalytic activity	IDA IDA: 通过直接分析推断	17255105	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10869435	GOA
located in cytosol	IDA IDA: 通过直接分析推断	31906564	GOA
located in nucleus	IDA IDA: 通过直接分析推断	31906564	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12963375	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YWHAB 蛋白结构

14-3-3

0
100
200
246 a.a.

蛋白主名

其他名称

14-3-3 protein beta/alpha

14-3-3 alpha

YWHAB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	YWHAB	P31946	CDK14	Homo sapiens	O94921	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	CDK14	Homo sapiens	O94921	Anti Bait CoIP	16775625
种属内	YWHAB	P31946	YAP1	Homo sapiens	P46937	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	YAP1	Homo sapiens	P46937	CoIP	17974916
种属内	YWHAB	P31946	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	YAP1	Homo sapiens	P46937	BioID	36931259
种属内	YWHAB	P31946	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	PTPN3	Homo sapiens	P26045	Anti Bait CoIP	17353931
种属内	YWHAB	P31946	CDC25B	Homo sapiens	P30305	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	CDC25B	Homo sapiens	P30305	CoIP	15173315
种属内	YWHAB	P31946	CDC25B	Homo sapiens	P30305	Y2H	7644510
种属内	YWHAB	P31946	DYRK1A	Homo sapiens	Q13627-2	Y2H	17229891
种属内	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	IF	21972092
种属内	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	Anti Bait CoIP	17353931
种属内	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	PLA	21972092
种属内	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	RND3	Homo sapiens	P61587	Pull Down	23622247
种属内	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Pull Down	15454081
种属内	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	SSH1	Homo sapiens	Q8WYL5	CoIP	15159416
种属内	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	Anti Bait CoIP	17353931
种属内	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	BioID	36931259
种属内	YWHAB	P31946	ADAM22	Homo sapiens	Q9P0K1-3	Anti Tag CoIP	16868027
种属内	YWHAB	P31946	ADAM22	Homo sapiens	Q9P0K1-3	Y2H	16868027
种属内	YWHAB	P31946	ALS2	Homo sapiens	A0A0S2Z5Q7	Validated Y2H	32814053
种属内	YWHAB	P31946	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Array	32814053
种属内	YWHAB	P31946	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Pooling	32814053
种属内	YWHAB	P31946	SPG11	Homo sapiens	Q96JI7	Pull Down	36096339
种属内	YWHAB	P31946	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	HDAC4	Homo sapiens	P56524	BioID	36931259
种属内	YWHAB	P31946	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	BioID	36931259
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	SLCA	17085597
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	YWHAG	Homo sapiens	P61981	SLCA	17085597
种属内	YWHAB	P31946	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	SLCA	17085597
种属内	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	BRAF	Homo sapiens	P15056	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	BRAF	Homo sapiens	P15056	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	BRAF	Homo sapiens	P15056	BioID	36931259
种属内	YWHAB	P31946	BRAF	Homo sapiens	P15056	Anti Bait CoIP	17353931
种属内	YWHAB	P31946	ZNF395	Homo sapiens	Q9H8N7	CoIP	17531190
种属内	YWHAB	P31946	ZNF395	Homo sapiens	Q9H8N7	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	DACT1	Homo sapiens	Q9NYF0	Y2H	21262972
种属内	YWHAB	P31946	DACT1	Homo sapiens	Q9NYF0	Anti Tag CoIP	21262972
种属内	YWHAB	P31946	DACT1	Homo sapiens	Q9NYF0	Anti Bait CoIP	21262972
种属内	YWHAB	P31946	TSC2	Homo sapiens	P49815	Pull Down	12438239
种属内	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	TSC2	Homo sapiens	P49815	BioID	36931259
种属内	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Bait CoIP	17353931
种属内	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	YWHAB	P31946	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	YWHAB	P31946	HTT	Homo sapiens	P42858	Y2H	17500595
种属内	YWHAB	P31946	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	YWHAB	P31946	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	16959763
种属内	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	CBL	Homo sapiens	P22681	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	CBL	Homo sapiens	P22681	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	CBL	Homo sapiens	P22681	Biochemical	11697890
种属内	YWHAB	P31946	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
种属内	YWHAB	P31946	SRPK2	Homo sapiens	P78362	CoIP	19592491
种属内	YWHAB	P31946	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
种属间	YWHAB	P31946	Zfp36	Mus musculus	P22893	CoIP	14688255
种属间	YWHAB	P31946	Rnd3	Mus musculus	P61588	Anti Tag CoIP	23622247
种属间	YWHAB	P31946	Rnd3	Mus musculus	P61588	Pull Down	23622247
种属内	YWHAB	P31946	BAD	Homo sapiens	Q92934	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	BAD	Homo sapiens	Q92934	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	BAD	Homo sapiens	Q92934	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Bait CoIP	17353931
种属内	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	MARK3	Homo sapiens	P27448	BioID	36931259
种属间	YWHAB	P31946	Gem	Mus musculus	P55041	Pull Down	15860732
种属间	YWHAB	P31946	Gem	Mus musculus	P55041	Pull Down	14701738
种属内	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Pull Down	18372248
种属内	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	CBX4	Homo sapiens	O00257	Anti Bait CoIP	22078878
种属内	YWHAB	P31946	CBX4	Homo sapiens	O00257	BioID	36931259
种属内	YWHAB	P31946	GEM	Homo sapiens	P55040	Pull Down	14701738
种属内	YWHAB	P31946	CDC25A	Homo sapiens	P30304	Y2H	7644510
种属内	YWHAB	P31946	CDC25A	Homo sapiens	P30304	Pull Down	7644510
种属内	YWHAB	P31946	CDC25A	Homo sapiens	P30304	Anti Bait CoIP	7644510
种属间	YWHAB	P31946	Synpo2	Mus musculus	Q91YE8	Pull Down	15883195
种属内	YWHAB	P31946	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	YWHAB	P31946	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	YWHAB	P31946	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	YWHAB	P31946	ATXN1	Homo sapiens	P54253	BioID	36931259
种属内	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	24255178
种属内	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	36931259
种属内	YWHAB	P31946	CHEK1	Homo sapiens	O14757	Anti Tag CoIP	35271311
种属内	YWHAB	P31946	CHEK1	Homo sapiens	O14757	Pull Down	20639859
种属内	YWHAB	P31946	GAB2	Homo sapiens	Q9UQC2	CoIP	19172738
种属内	YWHAB	P31946	GAB2	Homo sapiens	Q9UQC2	Anti Tag CoIP	33961781
种属内	YWHAB	P31946	GAB2	Homo sapiens	Q9UQC2	BioID	36931259

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 YWHAB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74439	14-3-3 beta Protein, Human (GST)	P31946 (M1-N246)	≥95%
HY-P74440	14-3-3 beta Protein, Human	P31946 (M1-N246)	≥95%
HY-P700304	14-3-3 beta Protein, Human (His)	P31946 (M1-N246)	≥95%

YWHAB 抗体

目录号	产品名	应用	反应物种
HY-P82204	14-3-3 beta Antibody (YA1949)	WB	Human, Rat
HY-P84258	14-3-3 beta Antibody (YA3955)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat

关联疾病

疾病名称

别名

Chlamydia

Chlamydial Infection	Chlamydia Trachomatis Infectious Disease
Chlamydial Disease	Chlamydia Infections

Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Chronic Meningitis

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Granuloma Inguinale

Donovanosis	Pudendal Ulcer
Granuloma Inguinale Tropicum	Granuloma Pudendi Tropicum

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15940	YWHAB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19757	Ywhab Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26254	Ywhab Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	YWHAB	VGNC	VGNC:48508
Rattus norvegicus	YWHAB	RGD	RGD:61998
Mus musculus	YWHAB	MGD	MGI:1891917
Felis catus	YWHAB	VGNC	VGNC:67154
Macaca mulatta	YWHAB	VGNC	VGNC:78819
Bos taurus	YWHAB	VGNC	VGNC:37044
Macaca fascicularis	YWHAB	NCBI	NCBI:101926442
Others	YWHAB	NCBI

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