2. Gene
  3. Knl1 - kinetochore scaffold 1 Gene

Knl1 - kinetochore scaffold 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Casc5; 2310043D08Rik; 5730505K17Rik

基因 ID: 76464 | 基因类型: protein coding

关于 Knl1

功能概要

Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Predicted to act upstream of or within cell division and chromosome segregation. Predicted to be located in acrosomal vesicle; kinetochore; and nuclear body. Predicted to be active in nucleus. Is expressed in telencephalon ventricular layer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly and primary autosomal recessive microcephaly 4. Orthologous to human KNL1 (kinetochore scaffold 1). [provided by Alliance of Genome Resources, Apr 2022]

Knl1 基因产物(2)

mRNA Protein Name
NM_001362732.1 NP_001349661.1 kinetochore scaffold 1 isoform 2
NM_029617.3 NP_083893.2 kinetochore scaffold 1 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in homologous chromosome orientation in meiotic metaphase I IMP
IMP: 通过突变表型推断
35167144 MGI
involved in positive regulation of meiosis I spindle assembly checkpoint IMP
IMP: 通过突变表型推断
35167144 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
35167144 MGI
located in kinetochore IDA
IDA: 通过直接分析推断
35167144 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

kinetochore scaffold 1

cancer susceptibility candidate 5

kinetochore-null protein 1

protein CASC5

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07412 KNL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22214 Knl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28736 Knl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Knl1 NCBI NCBI:57082
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