CA7 - carbonic anhydrase 7 Gene

中文名称：碳酸酐酶 7

种属: Homo sapiens

同用名: CAVII; CA-VII

关于 CA7

功能概要

碳酸酐酶是一大类锌金属酶，可催化二氧化碳的可逆水合。它们参与多种生物过程，包括呼吸、钙化、酸碱平衡、骨吸收以及房水、脑脊液、唾液和胃酸的形成。它们在组织分布和亚细胞定位方面表现出广泛的多样性。由该基因编码的胞质蛋白主要在大脑中表达，并有助于碳酸氢盐驱动的 GABA 能神经元兴奋。编码区的可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2018 年 8 月]

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the brain and contributes to bicarbonate driven GABAergic neuron excitation. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2018]