IL1R2 - interleukin 1 receptor type 2 Gene

中文名称：白介素 1 受体 2 型

种属: Homo sapiens

同用名: IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2

关于 IL1R2

功能概要

该基因编码的蛋白质是属于白介素 1 受体家族的细胞因子受体。这种蛋白质结合白细胞介素α (IL1A) 、白细胞介素β (IL1B) 和白细胞介素 1 受体 I 型 (IL1R1/IL1RA) ，并充当抑制其配体活性的诱饵受体。据报道，白细胞介素 4 (IL4) 通过诱导该细胞因子的表达和释放来拮抗白细胞介素 1 的活性。该基因和其他三个基因在染色体 2q12 上形成一个细胞因子受体基因簇。可变剪接导致多种转录本变体和蛋白质同种型。可变剪接产生膜结合蛋白和可溶性蛋白。可溶性蛋白质也通过蛋白水解切割产生。[RefSeq 提供，2012 年 5 月]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]