1. Gene
  2. Apaf1 - apoptotic peptidase activating factor 1 Gene

Apaf1 - apoptotic peptidase activating factor 1 Gene

种属: Rattus norvegicus

基因 ID: 78963 | 基因类型: protein coding

关于 Apaf1

功能概要

Enables heat shock protein binding activity and identical protein binding activity. Involved in several processes, including animal organ development; cardiac muscle cell apoptotic process; and cellular response to transforming growth factor beta stimulus. Located in cytoplasm. Part of apoptosome. Used to study visual epilepsy. Biomarker of brain ischemia; colon cancer; middle cerebral artery infarction; and muscular atrophy. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Apaf1 基因产物(1)

mRNA Protein Name
NM_023979.2 NP_076469.1 apoptotic protease-activating factor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
22143029 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17483091 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16979168 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
18197610 RGD
involved in cell differentiation IEP
IEP: 通过表达模式推断
15504912 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
11003619 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
27665619 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
18325779 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
14973070 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of apoptosome IDA
IDA: 通过直接分析推断
17483091 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

apoptotic protease-activating factor 1

apaf-1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Apaf1 NCBI NCBI:317
Mus musculus Apaf1 NCBI NCBI:11783