ST8SIA4 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Gene

中文名称：ST8 α-N-乙酰神经氨酸 α-2,8-唾液酸转移酶 4

种属: Homo sapiens

同用名: PST; PST1; SIAT8D; ST8SIA-IV

基因 ID: 7903 | 基因类型: protein coding

关于 ST8SIA4

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:100,806,933-100,903,282 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 5 paralogues. Broad expression in appendix (RPKM 6.6), lymph node (RPKM 4.8) and 19 other tissues.

功能概要

由该基因编码的蛋白质催化合成聚唾液酸所需的α-2,8-连接唾液酸的缩聚，聚唾液酸是神经细胞粘附分子 (NCAM1) 粘附特性的调节剂。编码的蛋白质是糖基转移酶家族 29 的成员，是一种 II 型膜蛋白，可能存在于高尔基体中。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of Glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ST8SIA4 基因产物(2)

mRNA	Protein	Name
NM_005668.6	NP_005659.1	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor
NM_175052.3	NP_778222.1	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform b precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IDA IDA: 通过直接分析推断	9774483	GOA
enables sialyltransferase activity	IDA IDA: 通过直接分析推断	28810663	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in N-glycan processing	IDA IDA: 通过直接分析推断	10766765	GOA
involved in ganglioside biosynthetic process	IDA IDA: 通过直接分析推断	10766765	GOA
involved in oligosaccharide metabolic process	IDA IDA: 通过直接分析推断	10766765	GOA
involved in protein glycosylation	IDA IDA: 通过直接分析推断	10766765	GOA
involved in sialylation	IDA IDA: 通过直接分析推断	7624364	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	9852130	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ST8SIA4 蛋白结构

Glyco_transf_29

0
100
200
300
359 a.a.

蛋白主名

其他名称

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase

关联疾病

疾病名称

别名

Dystonia 16

DYT16	Dyt-Prkra
Dystonia-16	Young-Onset Dystonia-
Early-Onset Dystonia Parkinsonism	Dystonia, Type 16

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-E70301	ST8 alpha-2,8-Sialyltransferase 4		/	否
HY-RS13858	ST8SIA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ST8SIA4	RGD	RGD:621845
Bos taurus	ST8SIA4	VGNC	VGNC:35346
Felis catus	ST8SIA4	VGNC	VGNC:65737
Macaca mulatta	ST8SIA4	VGNC	VGNC:77832
Mus musculus	ST8SIA4	MGD	MGI:106018
Canis familiaris	ST8SIA4	VGNC	VGNC:46866

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