2. Gene
  3. METTL16 - methyltransferase 16, N6-methyladenosine Gene

METTL16 - methyltransferase 16, N6-methyladenosine Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲基转移酶 16，N6-甲基腺苷

种属: Homo sapiens

同用名: METT10D

基因 ID: 79066 | 基因类型: protein coding

关于 METTL16

This gene has 10 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in ovary (RPKM 7.5), thyroid (RPKM 6.7) and 25 other tissues.

功能概要

启用 RNA 结合活性和 RNA 甲基转移酶活性。参与 RNA 修饰和 mRNA 代谢过程的调控。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity and RNA methyltransferase activity. Involved in RNA modification and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL16 基因产物(1)

mRNA Protein Name
NM_024086.4 NP_076991.3 RNA N6-adenosine-methyltransferase METTL16
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
27872311 GOA
enables RNA stem-loop binding IDA
IDA: 通过直接分析推断
28525753 GOA
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity IDA
IDA: 通过直接分析推断
28525753 GOA
enables U6 snRNA 3'-end binding IDA
IDA: 通过直接分析推断
28525753 GOA
enables mRNA m(6)A methyltransferase activity IDA
IDA: 通过直接分析推断
28525753 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of S-adenosylmethionine biosynthetic process IDA
IDA: 通过直接分析推断
28525753 GOA
involved in mRNA processing IDA
IDA: 通过直接分析推断
30197297 GOA
involved in negative regulation of 3'-UTR-mediated mRNA stabilization IDA
IDA: 通过直接分析推断
28525753 GOA
involved in post-transcriptional regulation of gene expression IDA
IDA: 通过直接分析推断
28525753 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28525753 GOA
involved in snRNA (adenine-N6)-methylation IDA
IDA: 通过直接分析推断
28525753 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
31940410 GOA
located in nucleus IDA
IDA: 通过直接分析推断
27872311 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

METTL16 蛋白结构

Methyltransf_10

Methyltransf_10: Protein of unknown function (DUF890) (1 - 291)

  • 0
  • 100
  • 200
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  • 500
  • 562 a.a.
蛋白主名 其他名称

RNA N6-adenosine-methyltransferase METTL16

N6-adenosine-methyltransferase METTL16

关联疾病

疾病名称 别名
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-161402 METTL16-IN-1 Inhibitor 99.22% 否
HY-162082 METTL1-WDR4-IN-2 Inhibitor 99.71% 否
HY-RS08357 METTL16 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23843 Mettl16 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17388 Mettl16 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus METTL16 MGD MGI:1914743
Felis catus METTL16 VGNC VGNC:63460
Macaca mulatta METTL16 VGNC VGNC:74603
Bos taurus METTL16 VGNC VGNC:55844
Canis familiaris METTL16 VGNC VGNC:43172
Rattus norvegicus METTL16 RGD RGD:1593242
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