2. Gene
  3. Dab2 - DAB adaptor protein 2 Gene

Dab2 - DAB adaptor protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Doc2; Doc-2

基因 ID: 79128 | 基因类型: protein coding

关于 Dab2

功能概要

Enables low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to growth factor stimulus; negative regulation of signal transduction; and positive regulation of transport. Located in clathrin-coated vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Used to study myocardial infarction. Biomarker of metabolic acidosis and myocardial infarction. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dab2 基因产物(1)

mRNA Protein Name
NM_024159.2 NP_077073.1 disabled homolog 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables low-density lipoprotein particle receptor binding IPI
IPI: 通过物理相互作用推断
16306401 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10769163 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to epidermal growth factor stimulus IDA
IDA: 通过直接分析推断
12473651 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
21762377 RGD
involved in clathrin coat assembly IMP
IMP: 通过突变表型推断
19000037 RGD
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
12473651 RGD
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
21762377 RGD
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
11371563 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
9681506 RGD
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
17317100 RGD
involved in positive regulation of aldosterone biosynthetic process IDA
IDA: 通过直接分析推断
17303656 RGD
involved in positive regulation of aldosterone secretion IDA
IDA: 通过直接分析推断
17303656 RGD
involved in positive regulation of endocytosis IDA
IDA: 通过直接分析推断
19000037 RGD
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
19000037 RGD
involved in regulation of Rho-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9681506 RGD
involved in response to salt IEP
IEP: 通过表达模式推断
17303656 RGD
involved in response to steroid hormone IMP
IMP: 通过突变表型推断
9681506 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in clathrin-coated vesicle membrane IDA
IDA: 通过直接分析推断
19000037 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
21080337 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

disabled homolog 2

C9

DAB2, clathrin adaptor protein

adaptor molecule disabled-2

differentially expressed in ovarian carcinoma 2

disabled 2, mitogen-responsive phosphoprotein

disabled homolog 2 mitogen-responsive phosphoprotein

mitogen-responsive phosphoprotein

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03511 DAB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03512 DAB2IP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20265 Dab2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26773 Dab2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-112114 DTPA-DAB2 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dab2 NCBI NCBI:1601
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