2. Gene
  3. APOO - apolipoprotein O Gene

APOO - apolipoprotein O Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：载脂蛋白 O

种属: Homo sapiens

同用名: MIC26; Mic23; My025; FAM121B; MICOS26

基因 ID: 79135 | 基因类型: protein coding

关于 APOO

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,833,353-23,907,938 (from NCBI)

This gene has 9 transcripts (splice variants), 293 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 9.7), brain (RPKM 7.6) and 25 other tissues.

功能概要

该基因是载脂蛋白家族的成员。该蛋白质家族的成员参与脂质的运输和代谢。编码的蛋白质与 HDL、LDL 和 VLDL 脂蛋白相关，其特征在于硫酸软骨素糖基化。这种蛋白质可能参与预防肥胖和糖尿病患者心肌中的脂质积累。可变剪接导致多个转录本变体。在 3、4、5、12 和 16 号染色体上发现了该基因的假基因。[RefSeq 提供，2009 年 9 月]

This gene is a member of the Apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

APOO 基因产物(1)

mRNA Protein Name
NM_024122.5 NP_077027.1 MICOS complex subunit MIC26 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25764979 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cristae formation IMP
IMP: 通过突变表型推断
25764979 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
25764979 GOA
part of MICOS complex IDA
IDA: 通过直接分析推断
25764979 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
25764979 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
25764979 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
25764979 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
24743151 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

APOO 蛋白结构

ApoO

ApoO: Apolipoprotein O (27 - 177)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

MICOS complex subunit MIC26

MICOS complex subunit MIC23

APOO 抗体

目录号 产品名 应用 反应物种
HY-P84764 ApoO Antibody (YA4461) WB, IHC-P, ELISA Human, Mouse

关联疾病

疾病名称 别名
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
Combined Oxidative Phosphorylation Deficiency 37

COXPD37
Barth Syndrome

3-Methylglutaconic Aciduria Type 2

BTHS

Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

Mga Type Ii

Mga2

Mgca2

Mga Type 2

3-Methylglutaconic Aciduria Type Ii

3-Methylglutaconic Aciduria, Type Ii

Mga, Type Ii

3-Methylglutaconicaciduria Type 2

3-Methylglutaconicaciduria Type Ii

Taz Defect

3 Methylglutaconic Aciduria, Type Ii

Dnajc19 Defect

Cardioskeletal Myopathy-Neutropenia Syndrome

X-Linked Cardioskeletal Myopathy And Neutropenia

3-Alpha-Methylglutaconic Aciduria Type 2

Agm2

Cardioskeletal Myopathy-Neutropenia

Invm

Left Ventricular Non-Compaction Isolated X-Linked

Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

Agammaglobulinemia 2, Autosomal Recessive
Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10

Cardiomyopathy And Cataract

Cataract And Cardiomyopathy

MTDPS10

Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

Senger Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00861 APOO Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19576 Apoo Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26073 Apoo Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus APOO MGD MGI:1915566
Bos taurus APOO VGNC VGNC:26035
Macaca mulatta APOO VGNC VGNC:103788
Rattus norvegicus APOO RGD RGD:1565289
Felis catus APOO VGNC VGNC:97354
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