2. Gene
  3. Slc6a1 - solute carrier family 6 member 1 Gene

Slc6a1 - solute carrier family 6 member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Gat1; Gabt1

基因 ID: 79212 | 基因类型: protein coding

关于 Slc6a1

功能概要

Enables gamma-aminobutyric acid:sodium symporter activity and identical protein binding activity. Involved in several processes, including gamma-aminobutyric acid import; negative regulation of GABAergic synaptic transmission; and positive regulation of gamma-aminobutyric acid secretion. Located in cell surface; neuron projection; and plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study brain ischemia. Biomarker of cerebral infarction; epilepsy; temporal lobe epilepsy; and withdrawal disorder. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a1 基因产物(1)

mRNA Protein Name
NM_024371.3 NP_077347.1 sodium- and chloride-dependent GABA transporter 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
IDA: 通过直接分析推断
1975955 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16314925 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11017172 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in gamma-aminobutyric acid import IDA
IDA: 通过直接分析推断
16378241 RGD
involved in learning IMP
IMP: 通过突变表型推断
12110474 RGD
involved in negative regulation of synaptic transmission, GABAergic IMP
IMP: 通过突变表型推断
17317750 RGD
involved in neurotransmitter reuptake IDA
IDA: 通过直接分析推断
1975955 RGD
involved in neurotransmitter reuptake IMP
IMP: 通过突变表型推断
1975955 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IMP
IMP: 通过突变表型推断
14500747 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
15778221 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
12832547 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
15664431 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
15149801 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: 通过表达模式推断
30275762 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17408599 RGD
involved in response to purine-containing compound IMP
IMP: 通过突变表型推断
16730753 RGD
involved in response to sucrose IEP
IEP: 通过表达模式推断
15778221 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
14500747 RGD
involved in response to toxic substance IMP
IMP: 通过突变表型推断
14643747 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
24368619 RGD
located in cell surface IDA
IDA: 通过直接分析推断
14500747 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
24368619 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
24368619 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sodium- and chloride-dependent GABA transporter 1

GABA transporter protein

GAT-1

solute carrier family 6 (neurotransmitter transporter), member 1

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13296 SLC6A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21939 Slc6a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28456 Slc6a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc6a1 NCBI NCBI:6529
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