2. Gene
  3. Hmgcl - 3-hydroxy-3-methylglutaryl-CoA lyase Gene

Hmgcl - 3-hydroxy-3-methylglutaryl-CoA lyase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 79238 | 基因类型: protein coding

关于 Hmgcl

功能概要

Enables carboxylic acid binding activity; fatty-acyl-CoA binding activity; and hydroxymethylglutaryl-CoA lyase activity. Involved in several processes, including acyl-CoA metabolic process; ketone body biosynthetic process; and liver development. Located in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcl 基因产物(1)

mRNA Protein Name
NM_024386.2 NP_077362.1 hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carboxylic acid binding IPI
IPI: 通过物理相互作用推断
2573547 RGD
enables fatty-acyl-CoA binding IPI
IPI: 通过物理相互作用推断
2573547 RGD
enables hydroxymethylglutaryl-CoA lyase activity IDA
IDA: 通过直接分析推断
2573547 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acyl-CoA metabolic process IDA
IDA: 通过直接分析推断
2573547 RGD
involved in ketone body biosynthetic process IDA
IDA: 通过直接分析推断
2573547 RGD
involved in liver development IEP
IEP: 通过表达模式推断
13990 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
10419135 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
5667251 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
5667251 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hydroxymethylglutaryl-CoA lyase, mitochondrial

3-hydroxy-3-methylglutarate-CoA lyase

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

3-hydroxymethyl-3-methylglutaryl-CoA lyase

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

HL

HMG-CoA lyase

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-176347S Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-RS06236 HMGCL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20953 Hmgcl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27470 Hmgcl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hmgcl NCBI NCBI:3155
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