SPAG16 - sperm associated antigen 16 Gene

中文名称：精子相关抗原 16

种属: Homo sapiens

同用名: PF20; WDR29

基因 ID: 79582 | 基因类型: protein coding

关于 SPAG16

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:213,284,464-214,410,501 (from NCBI)

This gene has 11 transcripts (splice variants) and 245 orthologues. Broad expression in testis (RPKM 2.7), thyroid (RPKM 1.2) and 24 other tissues.

功能概要

纤毛和鞭毛由微管骨架组成，轴丝由基体组织并被质膜包围。 SPAG16 编码 2 种主要蛋白质，分别与精子尾部的轴丝和减数分裂后生殖细胞的细胞核相关 (Zhang 等人，2007 [PubMed 17699735]) 。[OMIM 提供，2008 年 7 月]

Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]

SPAG16 基因产物(2)

mRNA	Protein	Name
NM_001025436.3	NP_001020607.1	sperm-associated antigen 16 protein isoform 2
NM_024532.5	NP_078808.3	sperm-associated antigen 16 protein isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in axoneme assembly	IMP IMP: 通过突变表型推断	17699735	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPAG16 蛋白结构

WD40

0
100
200
300
400
500
631 a.a.

蛋白主名

其他名称

sperm-associated antigen 16 protein

WD repeat domain 29

关联疾病

疾病名称

别名

Pulmonary Subvalvular Stenosis

Pulmonary Infundibular Stenosis	Congenital Infundibular Stenosis
Infundibular Pulmonic Stenosis	Infundibular Pulmonic Stenosis, Congenital
Subvalvular Pulmonic Stenosis

Brain Small Vessel Disease 2

Porencephaly 2	BSVD2
Gould Syndrome 2	Porencephaly 2, Formerly
Poren2, Formerly	Poren2

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13621	SPAG16 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SPAG16	VGNC	VGNC:80363
Macaca mulatta	SPAG16	VGNC	VGNC:77977
Mus musculus	SPAG16	MGD	MGI:1913972
Rattus norvegicus	SPAG16	RGD	RGD:1565062

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