RIC3 - RIC3 acetylcholine receptor chaperone Gene

中文名称：RIC3 乙酰胆碱受体伴侣

种属: Homo sapiens

同用名: RIC-3; AYST720; PRO1385

关于 RIC3

功能概要

该基因编码对胆碱酯酶 3 样家族抑制剂具有抗性的成员，该家族充当特定 5-羟色胺 3 型受体和烟碱型乙酰胆碱受体亚型的伴侣。编码的蛋白质影响这些受体亚基在内质网中的折叠和组装以及细胞表面的表达。该蛋白质包含一个 N 末端跨膜结构域、一个富含脯氨酸的间隔区和一个胞质 C 末端卷曲螺旋结构域。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 10 月]

This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]