2. Gene
  3. NDNF - neuron derived neurotrophic factor Gene

NDNF - neuron derived neurotrophic factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经源性神经营养因子

种属: Homo sapiens

同用名: HH25; NORD; C4orf31

基因 ID: 79625 | 基因类型: protein coding

关于 NDNF

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:121,035,613-121,072,535 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Biased expression in lung (RPKM 64.4), placenta (RPKM 31.0) and 9 other tissues.

功能概要

预测启用肝素结合活性。参与多个过程，包括细胞对缺氧的反应；细胞凋亡过程的负调控；和一氧化氮介导的信号转导。位于细胞外空间。与低促性腺激素性性腺功能减退有关。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Apr 2022]

NDNF 基因产物(1)

mRNA Protein Name
NM_024574.4 NP_078850.3 protein NDNF precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IDA
IDA: 通过直接分析推断
24706764 GOA
involved in cellular response to fibroblast growth factor stimulus IMP
IMP: 通过突变表型推断
31883645 GOA
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
24706764 GOA
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: 通过直接分析推断
24706764 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
20969804 GOA
involved in neuron migration IDA
IDA: 通过直接分析推断
20969804 GOA
involved in nitric oxide mediated signal transduction IDA
IDA: 通过直接分析推断
24706764 GOA
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
20969804 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
20969804 GOA
is active in extracellular space IDA
IDA: 通过直接分析推断
35037619 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
31883645 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDNF 蛋白结构

DUF2369

DUF2369: Uncharacterised conserved protein (DUF2369) (153 - 220)

DUF2369

DUF2369: Uncharacterised conserved protein (DUF2369) (287 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 568 a.a.
蛋白主名 其他名称

protein NDNF

fibronectin type-III domain-containing protein C4orf31

关联疾病

疾病名称 别名
Hypogonadotropic Hypogonadism 25 With Anosmia

HH25
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Hypogonadotropic Hypogonadism

Klinefelter Syndrome

Klinefelter'S Syndrome

Xxy Syndrome

Xxy Trisomy

Hypogonadotropism

47, Xxy

Congenital Idiopathic Hypogonadotropic Hypogonadism

Isolated Congenital Gonadotropin Deficiency

47,Xxy Syndrome

47, Xxy Syndrome

Klinefelters Syndrome

Hypogonadism

Klinefelter Syndrome In Males

Klinefelter Syndrome, Unspecified

Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Arthrogryposis, Distal, Type 1b

DA1B

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1b
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Retinitis Pigmentosa 19

RP19

Retinitis Pigmentosa-19

Retinitis Pigmentosa, Type 19
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09111 NDNF Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NDNF VGNC VGNC:31937
Mus musculus NDNF MGD MGI:1915419
Macaca mulatta NDNF VGNC VGNC:75027
Canis familiaris NDNF VGNC VGNC:43676
Felis catus NDNF VGNC VGNC:63752
Rattus norvegicus NDNF RGD RGD:1311080
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