MANEA - mannosidase endo-alpha Gene

中文名称：内α甘露糖苷酶

种属: Homo sapiens

同用名: ENDO; hEndo

关于 MANEA

功能概要

通过寡糖基转移酶复合物将预组装的寡糖 glucose-3-mannose-9-N-acetylglucosamine-2 从焦磷酸多酚转移到靶蛋白上的受体位点，在内质网 (ER) 中启动蛋白质的 N-糖基化。这种核心寡糖依次被高尔基体中的几种 ER 糖苷酶和内甘露糖苷酶 (EC 3.2.1.130) (例如 MANEA) 加工。 MANEA 通过切割将它们连接到高甘露糖聚糖的 α-1,2-甘露糖苷键来催化单糖、二糖和三糖基甘露糖寡糖的释放 (Hamilton 等人，2005 [PubMed 15677381]) 。[OMIM 提供, 2008 年 9 月]

N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]