1. Gene
  2. FZD3 - frizzled class receptor 3 Gene

FZD3 - frizzled class receptor 3 Gene

中文名称:卷曲类受体 3

种属: Homo sapiens

同用名: Fz-3

基因 ID: 7976 | 基因类型: protein coding

关于 FZD3

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,494,212-28,574,258 (from NCBI)

This gene has 4 transcripts (splice variants), 276 orthologues and 15 paralogues. Broad expression in brain (RPKM 6.0), ovary (RPKM 2.6) and 18 other tissues.

功能概要

该基因是卷曲基因家族的成员。该家族的成员编码七次跨膜结构域蛋白,这些蛋白是无翼型 MMTV 整合位点信号蛋白家族的受体。大多数 Frizzled 受体与 β-连环蛋白经典信号通路相耦合。这种蛋白质的功能尚不清楚,但它可能在哺乳动物毛囊发育中发挥作用。可变剪接导致多个转录本变体。该基因是精神分裂症的易感位点。[RefSeq 提供,2010 年 12 月]

This gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

FZD3 基因产物(18)

mRNA Protein Name
NM_001412905.1 NP_001399834.1 frizzled-3 isoform 2 precursor
NM_001412906.1 NP_001399835.1 frizzled-3 isoform 3
NM_001412907.1 NP_001399836.1 frizzled-3 isoform 4 precursor
NM_001412908.1 NP_001399837.1 frizzled-3 isoform 5
NM_001412909.1 NP_001399838.1 frizzled-3 isoform 6
NM_001412910.1 NP_001399839.1 frizzled-3 isoform 6
NM_001412911.1 NP_001399840.1 frizzled-3 isoform 1 precursor
NM_001412912.1 NP_001399841.1 frizzled-3 isoform 7
NM_001412913.1 NP_001399842.1 frizzled-3 isoform 7
NM_001412917.1 NP_001399846.1 frizzled-3 isoform 2 precursor
NM_001412919.1 NP_001399848.1 frizzled-3 isoform 6
NM_001412921.1 NP_001399850.1 frizzled-3 isoform 8 precursor
NM_001412922.1 NP_001399851.1 frizzled-3 isoform 9
NM_001412924.1 NP_001399853.1 frizzled-3 isoform 10
NM_001412925.1 NP_001399854.1 frizzled-3 isoform 10
NM_001412927.1 NP_001399856.1 frizzled-3 isoform 11
NM_017412.4 NP_059108.1 frizzled-3 precursor
NM_145866.2 NP_665873.1 frizzled-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
18256285 GOA
enables Wnt-protein binding IPI
IPI: 通过物理相互作用推断
19038973 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
20802536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19038973 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19038973 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FZD3 蛋白结构

Fz

Fz: Fz domain (28 - 134)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (192 - 515)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
蛋白主名 其他名称

frizzled-3

frizzled 3, seven transmembrane spanning receptor

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Multicystic Dysplastic Kidney

Multicystic Renal Dysplasia

Multicystic Kidney Dysplasia

Mcdk

Multiple Congenital Cysts Of Kidney

Developmental Multicystic Kidney

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

Fallopian Tube Serous Adenocarcinoma
Distal Arthrogryposis

Arthrogryposis Multiplex Congenita

Arthrogryposis

Congenital Multiple Arthrogryposis

Congenital Arthromyodysplasia

Fibrous Ankylosis Of Multiple Joints

Guerin-Stern Syndrome

Guérin-Stern Syndrome

Myodystrophia Fetalis Deformans

Otto Syndrome

Rocher-Sheldon Syndrome

Rossi Syndrome

Amc

Multiple Congenital Arthrogryposis

Arthrogryposis Syndrome

Arthrogryposis, Distal

Distal Arthrogryposis Syndrome

Freeman-Sheldon Syndrome

Arthrogryposis, Distal, Type 2b

Congenital Multiplex Arthrogryposis

Amyoplasia Congenita

Congenital Amyoplasia

Amc - [Arthrogryposis Multiplex Congenita]

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube

Schizophrenia 19

SCZD19

Schizophrenia 19 With Or Without An Affective Disorder

Schizophrenia 19, Susceptibility To

{Schizophrenia 19, Susceptibility To}

Substance-Induced Psychosis
Tethered Spinal Cord Syndrome

Spinal Dysraphism

Tethered Cord Syndrome

Occult Spinal Dysraphism

Occult Spinal Dysraphism Sequence

Segmental Vertebral Anomalies

Tethered Spinal Cord Disease

Tethered Cord

Spina Bifida Occulta

Cryptomerorachischisis

Spina Bifida Occulta With Tethered Spinal Cord

Sbo - [Spina Bifida Occulta]

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome

Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FZD3 VGNC VGNC:41031
Rattus norvegicus FZD3 RGD RGD:628814
Bos taurus FZD3 VGNC VGNC:58460
Mus musculus FZD3 MGD MGI:108476
Felis catus FZD3 VGNC VGNC:62405
Macaca mulatta FZD3 VGNC VGNC:72835
Others FZD3 NCBI