2. Gene
  3. SVEP1 - sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Gene

SVEP1 - sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Sushi，血管性血友病因子 A 型，含 EGF 和戊氨酸蛋白结构域 1

种属: Homo sapiens

同用名: CCP22; SELOB; SEL-OB; C9orf13; POLYDOM

基因 ID: 79987 | 基因类型: protein coding

关于 SVEP1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:110,365,248-110,579,741 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 39 paralogues. Biased expression in placenta (RPKM 31.0), fat (RPKM 15.2) and 13 other tissues.

功能概要

预测启用钙离子结合活性和染色质结合活性。预计参与表皮发育和淋巴管形态发生。预测作用于多个过程的上游或内部，包括 Tie 信号通路；淋巴循环；和淋巴管发育。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable calcium ion binding activity and chromatin binding activity. Predicted to be involved in epidermis development and lymph vessel morphogenesis. Predicted to act upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SVEP1 基因产物(1)

mRNA Protein Name
NM_153366.4 NP_699197.3 sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IDA
IDA: 通过直接分析推断
35802072 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
35802072 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of vasoconstriction IMP
IMP: 通过突变表型推断
35802072 GOA
involved in positive regulation of platelet activation IMP
IMP: 通过突变表型推断
36792666 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
27892606 GOA
located in nucleus IDA
IDA: 通过直接分析推断
27892606 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SVEP1 蛋白结构

VWA

VWA: von Willebrand factor type A domain (61 - 229)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (287 - 337)

Sushi

Sushi: Sushi repeat (SCR repeat) (355 - 407)

Sushi

Sushi: Sushi repeat (SCR repeat) (415 - 470)

HYR

HYR: HYR domain (538 - 619)

HYR

HYR: HYR domain (621 - 698)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (982 - 1029)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (1036 - 1083)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (1090 - 1137)

EGF

EGF: EGF-like domain (1174 - 1203)

EGF

EGF: EGF-like domain (1212 - 1242)

EGF

EGF: EGF-like domain (1250 - 1280)

EGF

EGF: EGF-like domain (1326 - 1356)

EGF

EGF: EGF-like domain (1364 - 1394)

Pentaxin

Pentaxin: Pentaxin family (1419 - 1597)

Sushi

Sushi: Sushi repeat (SCR repeat) (1605 - 1662)

Sushi

Sushi: Sushi repeat (SCR repeat) (1667 - 1720)

EGF_CA

EGF_CA: Calcium-binding EGF domain (1722 - 1760)

Sushi

Sushi: Sushi repeat (SCR repeat) (1766 - 1819)

Sushi

Sushi: Sushi repeat (SCR repeat) (1824 - 1877)

Sushi

Sushi: Sushi repeat (SCR repeat) (1882 - 1935)

Sushi

Sushi: Sushi repeat (SCR repeat) (1940 - 1993)

Sushi

Sushi: Sushi repeat (SCR repeat) (1998 - 2055)

Sushi

Sushi: Sushi repeat (SCR repeat) (2060 - 2113)

Sushi

Sushi: Sushi repeat (SCR repeat) (2123 - 2176)

Sushi

Sushi: Sushi repeat (SCR repeat) (2181 - 2236)

Sushi

Sushi: Sushi repeat (SCR repeat) (2241 - 2295)

Sushi

Sushi: Sushi repeat (SCR repeat) (2300 - 2353)

Sushi

Sushi: Sushi repeat (SCR repeat) (2358 - 2412)

Sushi

Sushi: Sushi repeat (SCR repeat) (2417 - 2470)

Sushi

Sushi: Sushi repeat (SCR repeat) (2475 - 2528)

Sushi

Sushi: Sushi repeat (SCR repeat) (2533 - 2585)

Sushi

Sushi: Sushi repeat (SCR repeat) (2644 - 2689)

Sushi

Sushi: Sushi repeat (SCR repeat) (2694 - 2747)

Sushi

Sushi: Sushi repeat (SCR repeat) (2752 - 2805)

Sushi

Sushi: Sushi repeat (SCR repeat) (2810 - 2863)

Sushi

Sushi: Sushi repeat (SCR repeat) (2868 - 2921)

Sushi

Sushi: Sushi repeat (SCR repeat) (2926 - 2979)

Sushi

Sushi: Sushi repeat (SCR repeat) (2984 - 3036)

Sushi

Sushi: Sushi repeat (SCR repeat) (3061 - 3094)

Sushi

Sushi: Sushi repeat (SCR repeat) (3099 - 3149)

Sushi

Sushi: Sushi repeat (SCR repeat) (3158 - 3213)

Sushi

Sushi: Sushi repeat (SCR repeat) (3218 - 3267)

Sushi

Sushi: Sushi repeat (SCR repeat) (3276 - 3329)

Sushi

Sushi: Sushi repeat (SCR repeat) (3334 - 3388)

Sushi

Sushi: Sushi repeat (SCR repeat) (3393 - 3445)

hEGF

hEGF: Human growth factor-like EGF (3496 - 3508)

  • 0
  • 600
  • 1200
  • 1800
  • 2400
  • 3000
  • 3548 a.a.
蛋白主名 其他名称

sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

CCP module-containing protein 22

关联疾病

疾病名称 别名
Autosomal Dominant Nonsyndromic Deafness 78

Dfna78
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14058 SVEP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21775 Svep1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28292 Svep1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SVEP1 RGD RGD:1588987
Canis familiaris SVEP1 VGNC VGNC:47006
Felis catus SVEP1 VGNC VGNC:65863
Mus musculus SVEP1 MGD MGI:1928849
Bos taurus SVEP1 VGNC VGNC:56985
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