2. Gene
  3. DOCK5 - dedicator of cytokinesis 5 Gene

DOCK5 - dedicator of cytokinesis 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胞质分裂因子 5

种属: Homo sapiens

基因 ID: 80005 | 基因类型: protein coding

关于 DOCK5

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,184,689-25,415,711 (from NCBI)

This gene has 12 transcripts (splice variants), 222 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues.

功能概要

该基因编码胞质分裂蛋白家族的一个成员。该家族的成员充当小 Rho 家族 G 蛋白的鸟嘌呤核苷酸交换因子。该基因编码的蛋白质被认为与衔接子 CRK 和 CRKL 相关，并在调节肠上皮细胞在胶原蛋白 IV 上的扩散和迁移方面发挥作用。小鼠和斑马鱼中的类似蛋白质也在成肌细胞融合中发挥作用。[RefSeq 提供，2016 年 10 月]

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on Collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]

DOCK5 基因产物(2)

mRNA Protein Name
NM_001322810.2 NP_001309739.1 dedicator of cytokinesis protein 5 isoform 2
NM_024940.8 NP_079216.4 dedicator of cytokinesis protein 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19004829 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of vascular associated smooth muscle contraction IMP
IMP: 通过突变表型推断
22158624 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
19004829 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
19004829 GOA
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
22158624 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
19004829 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOCK5 蛋白结构

SH3_1

SH3_1: SH3 domain (14 - 60)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (439 - 637)

DHR-2

DHR-2: Dock homology region 2 (1452 - 1634)

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  • 1500
  • 1870 a.a.
蛋白主名 其他名称

dedicator of cytokinesis protein 5

关联疾病

疾病名称 别名
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Li-Fraumeni Syndrome 1

Lfs1
Li-Fraumeni Syndrome 2

LFS2

Li-Fraumeni Syndrome, Type 2

Li-Fraumeni Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110100 CPYPP Inhibitor 98.51% 否
HY-164587 E197 Inhibitor / 否
HY-RS03927 DOCK5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-171274 DOCK5-IN-1 Inhibitor / 否
HY-RS17827 Dock5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24295 Dock5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DOCK5 MGD MGI:2652871
Rattus norvegicus DOCK5 RGD RGD:1306872
Bos taurus DOCK5 VGNC VGNC:28159
Felis catus DOCK5 VGNC VGNC:61574
Macaca mulatta DOCK5 VGNC VGNC:83995
Canis familiaris DOCK5 VGNC VGNC:40049
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