ULBP1 - UL16 binding protein 1 Gene

中文名称：UL16 结合蛋白 1

种属: Homo sapiens

同用名: N2DL-1; RAET1I; NKG2DL1

关于 ULBP1

功能概要

该基因编码的蛋白质是第 2 组自然杀伤细胞 D 成员 (NKG2D) 的配体，NKG2D 是 NK 细胞和 T 细胞上的一种免疫系统激活受体。编码的配体与 NKG2D 的结合导致几种信号转导通路的激活，包括 JAK2、STAT5、ERK 和 PI3K 激酶/Akt。此外，在巨细胞病毒感染的细胞中，该配体结合 UL16 糖蛋白并被阻止激活免疫系统。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]