1. Gene
  2. ACAD10 - acyl-CoA dehydrogenase family member 10 Gene

ACAD10 - acyl-CoA dehydrogenase family member 10 Gene

中文名称:酰基辅酶 A 脱氢酶家族成员 10

种属: Homo sapiens

基因 ID: 80724 | 基因类型: protein coding

关于 ACAD10

Cytogenetic location: 12q24.12 Genomic coordinates (GRCh38): 12:111,686,053-111,757,099 (from NCBI)

This gene has 24 transcripts (splice variants), 124 orthologues and 14 paralogues. Ubiquitous expression in kidney (RPKM 11.6), duodenum (RPKM 7.2) and 25 other tissues.

功能概要

该基因编码酰基辅酶 A 脱氢酶家族 (ACAD) 的成员,参与线粒体中脂肪酸的 β 氧化。编码的酶在 N 端部分包含一个水解酶结构域,在中心区域包含一个丝氨酸/苏氨酸蛋白激酶催化结构域,在 C 端包含一个保守的 ACAD 结构域。已经描述了该基因的几种可变剪接的转录本变体,但尚未确定其中一些变体的全长性质。[RefSeq 提供,2008 年 11 月]

This gene encodes a member of the acyl-CoA dehydrogenase family of Enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

ACAD10 基因产物(2)

mRNA Protein Name
NM_001136538.2 NP_001130010.1 acyl-CoA dehydrogenase family member 10 isoform a
NM_025247.6 NP_079523.3 acyl-CoA dehydrogenase family member 10 isoform b

ACAD10 蛋白结构

HAD_2

HAD_2: Haloacid dehalogenase-like hydrolase (45 - 229)

APH

APH: Phosphotransferase enzyme family (289 - 503)

Acyl-CoA_dh_N

Acyl-CoA_dh_N: Acyl-CoA dehydrogenase, N-terminal domain (664 - 787)

Acyl-CoA_dh_M

Acyl-CoA_dh_M: Acyl-CoA dehydrogenase, middle domain (791 - 845)

Acyl-CoA_dh_1

Acyl-CoA_dh_1: Acyl-CoA dehydrogenase, C-terminal domain (904 - 1052)

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  • 1059 a.a.
蛋白主名 其他名称

acyl-CoA dehydrogenase family member 10

ACAD-10

关联疾病

疾病名称 别名
Mitochondrial Complex I Deficiency, Nuclear Type 20

Acyl-Coa Dehydrogenase 9 Deficiency

Acad9 Deficiency

MC1DN20

Mitochondrial Complex I Deficiency Due To Acad9 Deficiency

Nuclear Type Mitochondrial Complex I Deficiency 20

Acyl-Coa Dehydrogenase Family, Member 9, Deficiency Of

Mitochondrial Complex 1 Deficiency Due To Acad9 Deficiency

Deficiency Of Acyl-Coa Dehydrogenase Family Member 9

Acyl-Coa Dehydrogenase Family, Member 9, Deficiency

Nuclear Type Mitochondrial Complex I Deficiency

Mc1dn

Mitochondrial Complex I Deficiency, Nuclear Type

Mitochondrial Complex I Deficiency, Nuclear

Mitochondrial Trifunctional Protein Deficiency

Tfp Deficiency

MTPD

Trifunctional Protein Deficiency

Trifunctional Protein Deficiency With Myopathy And Neuropathy

Tfpd

Familial Hypertrophic Cardiomyopathy

Cardiomyopathy Familial Hypertrophic

Familial Hcm

Heritable Hypertrophic Cardiomyopathy

Mtp Deficiency

Tpa Deficiency

Trifunctional Protein Deficiency, Type 2

Abetalipoproteinemia

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ACAD10 MGD MGI:1919235
Macaca mulatta ACAD10 VGNC VGNC:69495
Rattus norvegicus ACAD10 RGD RGD:1310159