2. Gene
  3. PRR7 - proline rich 7, synaptic Gene

PRR7 - proline rich 7, synaptic Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富脯氨酸 7，突触

种属: Homo sapiens

基因 ID: 80758 | 基因类型: protein coding

关于 PRR7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,445,995-177,456,286 (from NCBI)

This gene has 4 transcripts (splice variants), 122 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.0), brain (RPKM 0.9) and 12 other tissues.

功能概要

实现长链脂肪酸结合活性；蛋白酪氨酸激酶结合活性；和泛素样蛋白连接酶结合活性。参与蛋白质泛素化的负调控；凋亡过程的正调控；参与细胞凋亡信号通路的半胱氨酸型内肽酶活性的正调控。位于几种细胞成分中，包括细胞质；核质；和细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein Ligase binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PRR7 基因产物(5)

mRNA Protein Name
NM_001174101.2 NP_001167572.1 proline-rich protein 7
NM_001174102.3 NP_001167573.1 proline-rich protein 7
NM_001375593.1 NP_001362522.1 proline-rich protein 7
NM_001375594.1 NP_001362523.1 proline-rich protein 7
NM_030567.5 NP_085044.2 proline-rich protein 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables long-chain fatty acid binding IMP
IMP: 通过突变表型推断
21460222 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27458189 GOA
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
21460222 GOA
enables ubiquitin-like protein ligase binding IPI
IPI: 通过物理相互作用推断
27458189 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
21460222 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21460222 GOA
involved in regulation of transcription by RNA polymerase I IMP
IMP: 通过突变表型推断
27458189 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
21460222 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
21460222 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRR7 蛋白结构

WBP-1

WBP-1: WW domain-binding protein 1 (10 - 51)

  • 0
  • 100
  • 200
  • 274 a.a.
蛋白主名 其他名称

proline-rich protein 7

synaptic proline-rich membrane protein

关联疾病

疾病名称 别名
Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency

Isolated Succinate-Coenzyme Q Reductase Deficiency

Isolated Succinate-Coq Reductase Deficiency

Isolated Succinate-Ubiquinone Reductase Deficiency

Mitochondrial Respiratory Chain Complex Ii Deficiency

Complex 2 Mitochondrial Respiratory Chain Deficiency

Succinate Coq Reductase Deficiency

Succinate Dehydrogenase Deficiency

Isolated Succinate Dehydrogenase Deficiency

Succinate-Coenzyme Q Reductase Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11233 PRR7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22288 Prr7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28811 Prr7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PRR7 VGNC VGNC:110441
Canis familiaris PRR7 VGNC VGNC:45049
Mus musculus PRR7 MGD MGI:3487246
Felis catus PRR7 VGNC VGNC:102296
Rattus norvegicus PRR7 RGD RGD:1561898
Bos taurus PRR7 VGNC VGNC:33402
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