2. Gene
  3. CPTP - ceramide-1-phosphate transfer protein Gene

CPTP - ceramide-1-phosphate transfer protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-磷酸神经酰胺转移蛋白

种属: Homo sapiens

同用名: GLTPD1

基因 ID: 80772 | 基因类型: protein coding

关于 CPTP

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,324,802-1,328,896 (from NCBI)

This gene has 3 transcripts (splice variants), 338 orthologues and 5 paralogues. Broad expression in testis (RPKM 11.0), colon (RPKM 8.1) and 25 other tissues.

功能概要

启用神经酰胺 1-磷酸结合活性和神经酰胺 1-磷酸转移活性。参与多个过程，包括神经酰胺 1-磷酸转运； NLRP3 炎性体复合物组装的负调控；白细胞介素 1 β 生成的负调节。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in several processes, including ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CPTP 基因产物(1)

mRNA Protein Name
NM_001029885.2 NP_001025056.1 ceramide-1-phosphate transfer protein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ceramide 1-phosphate binding IDA
IDA: 通过直接分析推断
23863933 GOA
enables ceramide 1-phosphate transfer activity IDA
IDA: 通过直接分析推断
23863933 GOA
enables phospholipid binding IDA
IDA: 通过直接分析推断
23863933 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ceramide 1-phosphate transport IDA
IDA: 通过直接分析推断
23863933 GOA
NOT involved in glycolipid transport IDA
IDA: 通过直接分析推断
23863933 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IMP
IMP: 通过突变表型推断
29164996 GOA
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
29164996 GOA
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
29164996 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPTP 蛋白结构

GLTP

GLTP: Glycolipid transfer protein (GLTP) (26 - 177)

  • 0
  • 100
  • 200
  • 214 a.a.
蛋白主名 其他名称

ceramide-1-phosphate transfer protein

GLTP domain-containing protein 1

关联疾病

疾病名称 别名
Axenfeld-Rieger Syndrome, Type 1

Axenfeld-Rieger Syndrome Type 1

RIEG1

Rieg

Rgs

Rieger Syndrome Type 1

Rieger Syndrome, Type 1

Axenfeld-Rieger Syndrome 1

Iridogoniodysgenesis With Somatic Anomalies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03126 CPTP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18129 Cptp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24603 Cptp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CPTP MGD MGI:1933107
Bos taurus CPTP VGNC VGNC:27680
Felis catus CPTP VGNC VGNC:107518
Macaca mulatta CPTP VGNC VGNC:71599
Canis familiaris CPTP VGNC VGNC:39583
Rattus norvegicus CPTP RGD RGD:1359656
Others CPTP NCBI
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