APOL3 - apolipoprotein L3 Gene

中文名称：载脂蛋白 L3

种属: Homo sapiens

同用名: CG121; CG12_1; APOLIII; apoL-III

关于 APOL3

功能概要

该基因是载脂蛋白 L 基因家族的一员，与其他家族成员一起出现在 22 号染色体上。编码的蛋白质存在于细胞质中，可能会影响脂质 (包括胆固醇) 和/或允许脂质与细胞器结合。此外，该基因的表达在正常和动脉粥样硬化髂动脉和主动脉内壁的内皮细胞中被肿瘤坏死因子-α 上调。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 3 月]

This gene is a member of the Apolipoprotein L gene family, and it is present in a cluster with Other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including Cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]