2. Gene
  3. GRIP2 - glutamate receptor interacting protein 2 Gene

GRIP2 - glutamate receptor interacting protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氨酸受体相互作用蛋白 2

种属: Homo sapiens

基因 ID: 80852 | 基因类型: protein coding

关于 GRIP2

This gene has 7 transcripts (splice variants), 282 orthologues and 6 paralogues. Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues.

功能概要

预计可启用蛋白质 C 末端结合活性。预计参与多个过程，包括神经递质受体转运、核内体到突触后膜； AMPA 谷氨酸受体聚集的正向调节；兴奋性突触后电位的正向调节。预计作用于 Notch 信号通路的上游或内部；动脉平滑肌收缩；和血压的正向调节。预计位于细胞质中；树突轴；和神经元脊柱。预计在谷氨酸能突触和突触后密度中活跃。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]

GRIP2 基因产物(1)

mRNA Protein Name
NM_001080423.4 NP_001073892.3 glutamate receptor-interacting protein 2
蛋白主名 其他名称

glutamate receptor-interacting protein 2

关联疾病

疾病名称 别名
Fraser Syndrome 1

Fraser Syndrome

Cryptophthalmos With Other Malformations

Cryptophthalmos Syndrome

FRASRS1

Cryptophthalmos-Syndactyly Syndrome

Fraser-Francois Syndrome

Cyclopism

Meyer-Schwickerath'S Syndrome

Ulrich-Feichtiger Syndrome

Cryptophthalmos Syndactyly Syndrome

Fraser'S Syndrome

Meyer-Schwickerath Syndrome

Ullrich-Feichtiger Syndrome
Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6

Parkinson Disease 6

PARK6

Parkinson Disease 6, Early Onset

Parkinson'S Disease 6

Parkinson Disease 6, Early-Onset

Autosomal Recessive Early-Onset Parkinson'S Disease 6

Early-Onset Parkinson Disease 6

Autosomal Recessive Early-Onset Parkinson Disease Type 6

Parkinson Disease 6 Early-Onset

Parkinson Disease 6 Late-Onset Susceptibility To

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

Parkinsonism Young Adult Onset

Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

HPS1

Delta Storage Pool Disease

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Hermansky-Pudlak Syndrome, Type 1

Platelet Storage Pool Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05810 GRIP2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GRIP2 VGNC VGNC:73221
Bos taurus GRIP2 VGNC VGNC:29652
Felis catus GRIP2 VGNC VGNC:62715
Canis familiaris GRIP2 VGNC VGNC:41499
Rattus norvegicus GRIP2 RGD RGD:621668
Mus musculus GRIP2 MGD MGI:2681173
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