2. Gene
  3. KDM7A - lysine demethylase 7A Gene

KDM7A - lysine demethylase 7A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：赖氨酸脱甲基酶 7A

种属: Homo sapiens

同用名: JHDM1D

基因 ID: 80853 | 基因类型: protein coding

关于 KDM7A

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,084,746-140,176,983 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 9.6), colon (RPKM 7.1) and 25 other tissues.

功能概要

启用组蛋白去甲基化酶活性；甲基化组蛋白结合活性；和过渡金属离子结合活性。参与组蛋白赖氨酸去甲基化。位于核仁和核质中。与黑色素瘤有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables Histone Demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in histone lysine demethylation. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM7A 基因产物(1)

mRNA Protein Name
NM_030647.2 NP_085150.1 lysine-specific demethylase 7A
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: 通过直接分析推断
20023638 GOA
enables histone H3K27me2/H3K27me3 demethylase activity IDA
IDA: 通过直接分析推断
20023638 GOA
enables histone H3K36 demethylase activity IDA
IDA: 通过直接分析推断
20622853 GOA
enables histone H3K9 demethylase activity IDA
IDA: 通过直接分析推断
20023638 GOA
enables histone H4K20 demethylase activity IDA
IDA: 通过直接分析推断
20622853 GOA
enables iron ion binding IDA
IDA: 通过直接分析推断
20023638 GOA
enables methylated histone binding IDA
IDA: 通过直接分析推断
20023638 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
20023638 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KDM7A 蛋白结构

PHD

PHD: PHD-finger (39 - 86)

JmjC

JmjC: JmjC domain, hydroxylase (269 - 369)

  • 0
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  • 400
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  • 800
  • 941 a.a.
蛋白主名 其他名称

lysine-specific demethylase 7A

[histone H3]-dimethyl-L-lysine9 demethylase 7A

关联疾病

疾病名称 别名
Syndromic X-Linked Intellectual Disability Siderius Type

Mrxssd

Siderius-Hamel Syndrome

Siderius X-Linked Mental Retardation Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107573 KDM2/7-IN-1 Inhibitor 99.00% 否
HY-RS07224 KDM7A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19701 Kdm7a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26196 Kdm7a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KDM7A VGNC VGNC:63074
Canis familiaris KDM7A VGNC VGNC:51806
Rattus norvegicus KDM7A RGD RGD:1592650
Mus musculus KDM7A MGD MGI:2443388
Bos taurus KDM7A VGNC VGNC:30533
Macaca mulatta KDM7A VGNC VGNC:73886
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