1. Gene
  2. TRIM11 - tripartite motif containing 11 Gene

TRIM11 - tripartite motif containing 11 Gene

中文名称:含三方基序 11

种属: Homo sapiens

同用名: BIA1; RNF92

基因 ID: 81559 | 基因类型: protein coding

关于 TRIM11

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,393,676-228,406,835 (from NCBI)

This gene has 6 transcripts (splice variants), 96 orthologues and 80 paralogues. Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2,以及一个卷曲螺旋区域。该蛋白质定位于细胞核和细胞质。其功能尚未确定。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]

TRIM11 基因产物(1)

mRNA Protein Name
NM_145214.3 NP_660215.1 E3 ubiquitin-protein ligase TRIM11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16904669 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
27498865 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
27498865 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in innate immune response IMP
IMP: 通过突变表型推断
18248090 GOA
involved in negative regulation of AIM2 inflammasome complex assembly IDA
IDA: 通过直接分析推断
27498865 GOA
involved in negative regulation of viral entry into host cell IMP
IMP: 通过突变表型推断
18248090 GOA
involved in negative regulation of viral transcription IDA
IDA: 通过直接分析推断
18248090 GOA
involved in positive regulation of viral entry into host cell IMP
IMP: 通过突变表型推断
18248090 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
27498865 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
27498865 GOA
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 GOA
involved in suppression of viral release by host IMP
IMP: 通过突变表型推断
18248090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18248090 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM11 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (16 - 56)

zf-B_box

zf-B_box: B-box zinc finger (90 - 128)

PRY

PRY: SPRY-associated domain (289 - 337)

SPRY

SPRY: SPRY domain (339 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM11

RING finger protein 92

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRIM11 VGNC VGNC:79024
Canis familiaris TRIM11 VGNC VGNC:47804
Rattus norvegicus TRIM11 RGD RGD:1305448
Mus musculus TRIM11 MGD MGI:2137355
Felis catus TRIM11 VGNC VGNC:102353
Bos taurus TRIM11 VGNC VGNC:36313