2. Gene
  3. Creb1 - cAMP responsive element binding protein 1 Gene

Creb1 - cAMP responsive element binding protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Creb

基因 ID: 81646 | 基因类型: protein coding

关于 Creb1

功能概要

Enables several functions, including HSP70 protein binding activity; Arrestin family protein binding activity; and Histone Acetyltransferase binding activity. Involved in several processes, including cellular response to growth factor stimulus; learning or memory; and regulation of gene expression. Located in several cellular components, including axon; chromatin; and mitochondrial matrix. Part of transcription regulator complex. Used to study transient cerebral ischemia. Biomarker of Huntington's disease; brain ischemia; and sciatic neuropathy. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Creb1 基因产物(2)

mRNA Protein Name
NM_031017.2 NP_112279.1 cyclic AMP-responsive element-binding protein 1 isoform B
NM_134443.2 NP_604392.2 cyclic AMP-responsive element-binding protein 1 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
12697699 RGD
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12409294 RGD
enables Hsp70 protein binding IPI
IPI: 通过物理相互作用推断
16207717 RGD
enables arrestin family protein binding IPI
IPI: 通过物理相互作用推断
21223624 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
12697699 RGD
enables histone acetyltransferase binding IPI
IPI: 通过物理相互作用推断
22357921 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19196971 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12697699 RGD
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
21367864 RGD
enables transcription cis-regulatory region binding IMP
IMP: 通过突变表型推断
16382163 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
9413984 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell differentiation IMP
IMP: 通过突变表型推断
31678682 RGD
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
16382163 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: 通过表达模式推断
23865718 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
18193038 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
21505978 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
21308733 RGD
involved in chemotaxis to arachidonate IMP
IMP: 通过突变表型推断
16382163 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
21367864 RGD
involved in memory IMP
IMP: 通过突变表型推断
16687181 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
30566056 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
21816899 RGD
involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly IMP
IMP: 通过突变表型推断
16891311 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
24189100 RGD
involved in positive regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
16000619 RGD
involved in positive regulation of membrane depolarization IMP
IMP: 通过突变表型推断
16641242 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12409294 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16891311 RGD
involved in positive regulation of transforming growth factor beta3 production IMP
IMP: 通过突变表型推断
16891311 RGD
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
12939230 RGD
involved in regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
19285017 RGD
involved in regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
19365572 RGD
involved in response to L-glutamate IEP
IEP: 通过表达模式推断
19365572 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
25031400 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
27664298 RGD
involved in response to dehydroepiandrosterone IEP
IEP: 通过表达模式推断
22523357 RGD
involved in response to erythropoietin IDA
IDA: 通过直接分析推断
17368520 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
9581644 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
18322102 RGD
involved in response to hypobaric hypoxia IEP
IEP: 通过表达模式推断
22523357 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
24084215 RGD
involved in response to morphine IEP
IEP: 通过表达模式推断
19324071 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
22952905 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
21223624 RGD
involved in transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12697699 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
16891311 RGD
involved in visual learning IMP
IMP: 通过突变表型推断
25031400 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
18193038 RGD
located in chromatin IDA
IDA: 通过直接分析推断
15632413 RGD
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
16207717 RGD
located in nucleus IDA
IDA: 通过直接分析推断
19033670 RGD
part of transcription regulator complex IDA
IDA: 通过直接分析推断
15632413 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclic AMP-responsive element-binding protein 1

CREB-1

Y protein

cAMP response element binding protein 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03148 CREB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-P4497 Prolylserine Inhibitor / 否
HY-RS18270 Creb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24748 Creb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Creb1 NCBI NCBI:1385
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