2. Gene
  3. Mapk14 - mitogen activated protein kinase 14 Gene

Mapk14 - mitogen activated protein kinase 14 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：有丝分裂原活化蛋白激酶 14

种属: Rattus norvegicus

同用名: RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha

基因 ID: 81649 | 基因类型: protein coding

关于 Mapk14

Primary_assembly 20: 6,749,670-6,810,589 forward strand.mRatBN7.2:CM026993.1

This gene has 6 transcripts (splice variants), 295 orthologues, 21 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 267.1), Adrenal (RPKM 258.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动； MAP 激酶活性；和蛋白质 C 末端结合活性。参与多个过程，包括蛋白质自身磷酸化；对葡萄糖的反应；和应激激活的 MAPK 级联。位于细胞质和细胞核中。用于研究糖尿病性神经病变和骨质疏松症。阿尔茨海默病和抗基底膜肾小球肾炎的生物标志物。与人 MAPK14（丝裂原活化蛋白激酶 14）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; MAP kinase activity; and protein C-terminus binding activity. Involved in several processes, including protein autophosphorylation; response to glucose; and stress-activated MAPK cascade. Located in cytosol and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease and anti-basement membrane glomerulonephritis. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 基因产物(1)

mRNA Protein Name
NM_031020.3 NP_112282.2 mitogen-activated protein kinase 14
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
16879317 RGD
enables MAP kinase activity IDA
IDA: 通过直接分析推断
16407200 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
21607062 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
33409963 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23589286 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
16407200 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
16407200 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
18579738 RGD
involved in stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
16407200 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mapk14 蛋白结构

STKc_p38alpha

STKc_p38alpha: cd07877 (5 - 349)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 14

Csaids binding protein

MAP kinase 14

MAP kinase 2

MAP kinase Mxi2

MAP kinase p38 alpha

MAPK 14

MAX-interacting protein 2

cytokine suppressive anti-inflammatory drug binding protein

cytokine-supressive anti-inflammatory drug binding protein

mitogen-activated protein kinase 14A

mitogen-activated protein kinase p38 alpha

p38 MAP kinase

p38 mitogen activated protein kinase

p38alpha Exip

reactive kinase

stress-activated protein kinase 2A

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-10401 VX-702 Inhibitor 99.54% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18874 p38-α MAPK-IN-1 Inhibitor 99.89% 否
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-RS08108 Mapk14 Mouse Pre-designed siRNA Set A / 否
HY-RS08107 MAPK14 Human Pre-designed siRNA Set A / 否
HY-RS08109 Mapk14 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapk14 NCBI NCBI:1432
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