2. Gene
  3. ITPR2 - Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 Gene

ITPR2 - Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 81678 | 基因类型: protein coding

关于 ITPR2

功能概要

Enables calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Located in axon; endoplasmic reticulum; and myelin sheath. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

ITPR2 基因产物(1)

mRNA Protein Name
NM_031046.4 NP_112308.2 inositol 1,4,5-trisphosphate receptor type 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
10969001 RGD
enables inositol 1,4,5 trisphosphate binding IDA
IDA: 通过直接分析推断
10969001 RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: 通过直接分析推断
10620513 RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IMP
IMP: 通过突变表型推断
23166348 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
23884412 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
17285299 RGD
involved in release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
23166348 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
17091480 RGD
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
10969001 RGD
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
16014380 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

inositol 1,4,5-trisphosphate receptor type 2

IP3 receptor

IP3R 2

inositol 1,4,5-triphosphate receptor 2

inositol 1,4,5-triphosphate receptor, type 2

inositol triphosphate receptor type 2

insP3R2

type 2 InsP3 receptor

type 2 inositol 1,4,5-trisphosphate receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06992 ITPR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20971 Itpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27488 Itpr2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ITPR2 NCBI NCBI:3709
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