SELENOO - selenoprotein O Gene

中文名称：硒蛋白 O

种属: Homo sapiens

同用名: SELO

关于 SELENOO

功能概要

该基因编码一种定位于线粒体的硒蛋白。它是最大的哺乳动物硒蛋白，含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。这种硒蛋白的确切功能尚不清楚，但被认为具有氧化还原活性。[RefSeq 提供，2016 年 12 月]

This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]