1. Gene
  2. SELENOO - selenoprotein O Gene

SELENOO - selenoprotein O Gene

中文名称:硒蛋白 O

种属: Homo sapiens

同用名: SELO

基因 ID: 83642 | 基因类型: protein coding

关于 SELENOO

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,201,011-50,217,616 (from NCBI)

This gene has 2 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in bone marrow (RPKM 10.3), liver (RPKM 10.3) and 25 other tissues.

功能概要

该基因编码一种定位于线粒体的硒蛋白。它是最大的哺乳动物硒蛋白,含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码,通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构,称为 Sec 插入序列 (SECIS) 元件,这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。这种硒蛋白的确切功能尚不清楚,但被认为具有氧化还原活性。[RefSeq 提供,2016 年 12 月]

This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

SELENOO 基因产物(1)

mRNA Protein Name
NM_031454.2 NP_113642.1 protein adenylyltransferase SelO, mitochondrial
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables AMPylase activity IDA
IDA: 通过直接分析推断
30270044 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein adenylylation IDA
IDA: 通过直接分析推断
30270044 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
24751718 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SELENOO 蛋白结构

UPF0061

UPF0061: Uncharacterized ACR, YdiU/UPF0061 family (85 - 627)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
蛋白主名 其他名称

protein adenylyltransferase SelO, mitochondrial

关联疾病

疾病名称 别名
Staphyloenterotoxemia

Staphylococcal Food Poisoning

Staphylococcal Toxaemia Due To Food

Staphyloenterotoxicosis

Epidermolysis Bullosa Simplex 5a, Ogna Type

Epidermolysis Bullosa Simplex, Ogna Type

EBS5A

Ebsog

Epidermolysis Bullosa Simplex Ogna Type

Ebs-Og

Ebs-O

Plec-Related Intermediate Epidermolysis Bullosa Simplex Without Extracutaneous Involvement

Plec-Related Intermediate Ebs Without Extracutaneous Involvement

Ebs1

Ebso

Epidermolysis Bullosa Simplex 1

O-Ebs

Simplex Epidermolysis Bullosa_ogna Type

Commensal Bacterial Infectious Disease
Ritter'S Disease

Staphylococcal Scalded Skin Syndrome

Pemphigus Neonatorum

Ritter Disease

Dermatitis Exfoliativa Neonatorum

Scalded Skin Syndrome

Toxic Epidermal Necrolysis, Subcorneal Type

Generalized Exfoliative Disease

Ssss

Ssss - [Staphylococcal Scalded Skin Syndrome]

Rocky Mountain Spotted Fever

Brazillian Spotted

Choix

Exanthematic Typhus Of Sao Paulo

Fiebre Maculosa

Fiebre Manchada

Sao Paulo Typhus

So Paulo Fever

Tick Typhus

Tobia Fever

Rmsf

Typhus, Tick

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SELENOO VGNC VGNC:109513
Bos taurus SELENOO VGNC VGNC:58445
Rattus norvegicus SELENOO RGD RGD:1311907
Mus musculus SELENOO MGD MGI:1919007
Canis familiaris SELENOO VGNC VGNC:54544
Macaca mulatta SELENOO VGNC VGNC:98474