2. Gene
  3. TMEM175 - transmembrane protein 175 Gene

TMEM175 - transmembrane protein 175 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜蛋白 175

种属: Homo sapiens

同用名: hTMEM175

基因 ID: 84286 | 基因类型: protein coding

关于 TMEM175

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:932,460-958,656 (from NCBI)

This gene has 22 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in spleen (RPKM 10.8), brain (RPKM 6.7) and 25 other tissues.

功能概要

启用钾离子泄漏通道活动。参与钾离子跨膜转运。位于核内体和溶酶体中。是内体膜的组成部分和溶酶体膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables potassium ion leak channel activity. Involved in potassium ion transmembrane transport. Located in endosome and lysosome. Is integral component of endosome membrane and integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM175 基因产物(7)

mRNA Protein Name
NM_001297423.2 NP_001284352.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297424.2 NP_001284353.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297425.2 NP_001284354.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297426.2 NP_001284355.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297427.2 NP_001284356.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297428.2 NP_001284357.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_032326.4 NP_115702.1 endosomal/lysosomal potassium channel TMEM175 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arachidonate binding IDA
IDA: 通过直接分析推断
35750034 GOA
enables potassium channel activity IDA
IDA: 通过直接分析推断
28723891 GOA
enables potassium ion leak channel activity IDA
IDA: 通过直接分析推断
26317472 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
33505021 GOA
enables proton channel activity IDA
IDA: 通过直接分析推断
35333573 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lysosomal lumen pH elevation IDA
IDA: 通过直接分析推断
35333573 GOA
involved in potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
26317472 GOA
involved in proton transmembrane transport IDA
IDA: 通过直接分析推断
35333573 GOA
involved in regulation of lysosomal lumen pH IDA
IDA: 通过直接分析推断
35750034 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
26317472 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
32228865 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
35750034 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
32228865 GOA
located in lysosome IDA
IDA: 通过直接分析推断
26317472 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMEM175 蛋白结构

DUF1211

DUF1211: Protein of unknown function (DUF1211) (34 - 124)

DUF1211

DUF1211: Protein of unknown function (DUF1211) (259 - 356)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
蛋白主名 其他名称

endosomal/lysosomal potassium channel TMEM175

endosomal/lysomomal potassium channel TMEM175

关联疾病

疾病名称 别名
Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-33878 2-PPA Inhibitor 99.70% 否
HY-161949 AP-6 Inhibitor 99.84% 否
HY-RS29457 TMEM175 Monkey Pre-designed siRNA Set A Pre-designed Set / 否
HY-162666 TMEM175 modulator 1 Modulator / 否
HY-RS14683 TMEM175 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19555 Tmem175 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26051 Tmem175 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TMEM175 VGNC VGNC:79736
Bos taurus TMEM175 VGNC VGNC:35999
Felis catus TMEM175 VGNC VGNC:66291
Rattus norvegicus TMEM175 RGD RGD:1309712
Mus musculus TMEM175 MGD MGI:1919642
Canis familiaris TMEM175 VGNC VGNC:47500
Others TMEM175 NCBI
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