THOC3 - THO complex subunit 3 Gene

中文名称：THO 复合亚基 3

种属: Homo sapiens

同用名: THO3; hTREX45

关于 THOC3

功能概要

该基因编码核 THO 转录延伸复合物的一个组成部分，该复合物是耦合信使 RNA 加工和输出的较大转录输出 (TREX) 复合物的一部分。在人类中，转录输出复合体以剪接和帽依赖性方式被募集到信使 RNA 的 5' 端。对小鼠相关复合体的研究表明，后生动物转录输出复合体参与细胞分化和发育。该基因的假基因已在 5 号染色体上定义。[RefSeq 提供，2013 年 5 月]

This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]