2. Gene
  3. Foxo1 - forkhead box O1 Gene

Foxo1 - forkhead box O1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Fkhr; Foxo1a

基因 ID: 84482 | 基因类型: protein coding

关于 Foxo1

功能概要

Enables DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]

Foxo1 基因产物(1)

mRNA Protein Name
NM_001191846.3 NP_001178775.1 forkhead box protein O1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
10960473 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17916612 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
19273580 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
19443572 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
22417654 RGD
involved in enamel mineralization IEP
IEP: 通过表达模式推断
25183529 RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress IMP
IMP: 通过突变表型推断
26436652 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17916612 RGD
involved in positive regulation of smooth muscle cell apoptotic process IMP
IMP: 通过突变表型推断
19483080 RGD
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10960473 RGD
involved in regulation of transcription initiation by RNA polymerase II IMP
IMP: 通过突变表型推断
19483080 RGD
involved in response to fluoride IEP
IEP: 通过表达模式推断
25183529 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
20501667 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19483080 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

forkhead box protein O1

Forkhead box protein O1A

Forkhead in rhabdomyosarcoma

forkhead box O1A (rhabdomyosarcoma)

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N2440 Gypenoside A Activator 99.42% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Foxo1 NCBI NCBI:2308
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