2. Gene
  3. Setdb1 - SET domain, bifurcated 1 Gene

Setdb1 - SET domain, bifurcated 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ESET; KMT1E; mKIAA0067

基因 ID: 84505 | 基因类型: protein coding

关于 Setdb1

功能概要

Enables DNA binding activity; Histone Methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within several processes, including histone H3-K9 trimethylation; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; long bone; oocyte; and white fat. Human ortholog(s) of this gene implicated in autistic disorder and lung Cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Setdb1 基因产物(3)

mRNA Protein Name
NM_001163641.1 NP_001157113.1 histone-lysine N-methyltransferase SETDB1 isoform a
NM_001163642.1 NP_001157114.1 histone-lysine N-methyltransferase SETDB1 isoform b
NM_018877.3 NP_061365.3 histone-lysine N-methyltransferase SETDB1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
22495301 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
22079090 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: 通过直接分析推断
11791185 MGI
enables histone H3K9 methyltransferase activity IMP
IMP: 通过突变表型推断
22079090 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
20164836 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11791185 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
22876197 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: 通过突变表型推断
14993285 MGI
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: 通过突变表型推断
20164836 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22079090 MGI
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
20164836 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
14993285 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase SETDB1

ERG-associated protein with SET domain

SET domain ERG-associated histone methyltransferase

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141539 SETDB1-TTD-IN-1 99.93% 否
HY-141539A SETDB1-TTD-IN-1 TFA 99.77% 否
HY-173156 UNC10013 Modulator / 否
HY-168992 UNC6535 Inhibitor / 否
HY-RS12748 SETDB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16697 Setdb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23131 Setdb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Setdb1 NCBI NCBI:9869
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